Evidence map›Paper›PMID 42898378›Full record

ArticleBioImpacts : BI2026

Saponin conjugation improves p-CRISPR delivery by polyethylenimine modified carbon dots.

Ali Hamad Abd Kelkawi, Seyede Mahtab Kamrani Mousavi, Akbar Hasanzadeh, Sara Saeedi, Behjat Kheiri Yeganeh Azar, Babak Kamali, Seyyed Emad Hooshmand, Mohadese Rastgoo Korande, Michael R Hamblin, Jawdat N Gaaib and 1 more

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Article in BioImpacts : BI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Ali Hamad Abd KelkawiCollege of Nursing, University of Al-Ameed, Karbala, Iraq.ORCID https://orcid.org/0000-0001-7102-8789
Seyede Mahtab Kamrani MousaviCellular and molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
Akbar HasanzadehCellular and molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
Sara SaeediCellular and molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
Behjat Kheiri Yeganeh AzarDepartment of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.
Babak KamaliCellular and molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
Seyyed Emad HooshmandCellular and molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
Mohadese Rastgoo KorandeAdvanced Nanobiotechnology and Nanomedicine Research Group (ANNRG), Iran University of Medical Sciences, Tehran, Iran.
Michael R HamblinLaser Research Center, Faculty of Health Science, University of Johannesburg, Doornfontein 2028, South Africa.
Jawdat N GaaibDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, University of Kerbala, Karbala, Iraq.
Mahdi KarimiCellular and molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0002-7977-3940

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Non-toxic and efficient delivery platforms are important for gene editing applications. In this report, the preparation of saponin-conjugated low molecular weight polyethyleneimine (PEI Methods: Polyethyleneimine modified carbon dots (CD-PEI Results: These 80 nm nanoparticle vectors not only transfected green fluorescent protein plasmid (p-GFP) (3 kb) with 60% expression in human embryonic kidney (HEK 293T) cells, and>60% in hard to transfect human breast adenocarcinoma cells (MCF7), but could also transfect a large clustered regularly interspaced short palindromic repeat plasmid (p-CRISPR) with 5-fold higher efficiency (50%) than the gold standard reagent, branched PEI MWt 25 kDa (PEI Conclusion: This system demonstrated efficient transfection and serum resistance, making it a promising tool for future gene editing research.

Indexed as

CRISPRGene editing vectorPolyethylenimine carbon dotsSaponinSerum-resistance

Identifiers

PMID42898378
PMCPMC13677597

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.