ReviewFrontiers in immunology2026
Primary ocular adnexal MALT lymphoma involving the upper eyelid in a young woman: a case report and literature review.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary ocular adnexal MALT lymphoma (POAML) is a rare indolent small B-cell lymphoma that primarily involves the orbit, conjunctiva, and lacrimal gland, with a high risk of early misdiagnosis. Herein, we report a rare case of POAML arising in the right upper eyelid of a 35-year-old woman, who presented with progressive eyelid swelling. The diagnosis was established by surgical excision, histopathological examination, and immunoglobulin gene rearrangement analysis. No systemic involvement was identified, and the disease was staged as Ann Arbor IE. The patient received local radiotherapy (28 Gy) and achieved complete remission, remaining disease-free during a 3.5-year follow-up. Literature review indicates that POAML predominantly affects middle-aged and elderly individuals, although younger age and female predominance have been reported in Asian populations. Clinical manifestations vary by site and include orbital mass, proptosis, globe displacement, and ocular motility restriction. Conjunctival lesions typically present as hyperemia, chemosis, or a characteristic "salmon-pink" appearance. Histologically, POAML is characterized by diffuse proliferation of centrocyte-like cells, follicular colonization, and lymphoepithelial lesions (LELs), with CD20 and CD79a positivity. Previous studies have identified recurrent molecular alterations in POAML, including changes affecting the BCR/NF-κB, epigenetic, and NOTCH signaling pathways; rearrangements of
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.