Evidence map›Paper›PMID 42898277›Full record

ArticleFrontiers in neurology2026

Longitudinal dynamics of serum neurofilament light chain and prognostic value for functional outcome after acute stroke: a prospective cohort study.

Guangyong Chen, Yuxin Zhu, Feng Chen, Changhao Zhang, Jin Huang, Weijie Wu, Lei Chen, Lingling Lin, Yueping Chen, Anqi Lin and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Guangyong Chen *Department of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Yuxin Zhu *The First School of Medicine, School of Information and Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Feng Chen *The Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Changhao ZhangThe Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Jin HuangDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Weijie WuDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Lei ChenClinical Laboratory, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Lingling LinDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Yueping ChenClinical Laboratory, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Anqi LinRenji College, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Qinqin LiuDepartment of Rehabilitation Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Peipei WangDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Lidong ZhuDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Xuerong HuangDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Serum neurofilament light chain (sNfL) is a blood biomarker of neuroaxonal injury, but its early longitudinal dynamics and prognostic value in clinically heterogeneous acute stroke populations remain insufficiently defined. This study characterized early sNfL changes and examined their association with functional outcome after acute stroke. Methods: This prospective cohort study consecutively enrolled 104 patients with acute stroke and 86 healthy controls (HCs) between January 2023 and December 2024. Patients were grouped as intracerebral hemorrhage (ICH, Results: sNfL increased significantly from D1 to D7 ( Conclusion: sNfL levels increased during the first week after acute stroke. Higher D1 sNfL was associated with poor functional outcome at 3 and 6 months, suggesting potential value for early prognostic assessment.

Indexed as

Ischemic StrokeNeurofilament ProteinsStrokeAgedBiomarkersFemaleHumansLongitudinal StudiesMaleMiddle AgedPrognosisProspective StudiesRecovery of FunctionBiomarkersneurofilament protein LNeurofilament Proteinsbiomarkerfunctional outcomelongitudinal dynamicsserum neurofilament light chain (sNfL)stroke

Identifiers

PMID42898277
PMCPMC13677471

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