Evidence map›Paper›PMID 42898245›Full record

ReviewBiochemistry and biophysics reports2026

Targeting ferroptosis in cancer: molecular mechanisms and emerging therapeutic strategies.

Mansoor Khaledi, Hasti Ahani, Faezeh Rezaei Tohid, Fatemeh Kazemi, Elham Amirkhani, Zeynab Daliri, Sahar Yadegari, Kosar Moarefvand, Behnam Poureslamfar, Fatemeh Sameni and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Review in Biochemistry and biophysics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mansoor KhalediCellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Hasti AhaniDepartment of Surgery, Razi Clinical Research Development Unit, Guilan University of Medical Sciences, Rasht, Iran.
Faezeh Rezaei TohidDepartment of Molecular Cell Biology, Faculty of Animal Science, Sari Agricultural Sciences and Natural Resources University, Sari, Iran.
Fatemeh KazemiMedical Student, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
Elham AmirkhaniDepartment of General Medicine, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
Zeynab DaliriDepartment of Biology, Division of Cell and Developmental Biology, Faculty of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Sahar YadegariMedical Laboratory Supervisor, Department of Medical Laboratory Sciences, Faculty of Medical Sciences, Islamic Azad University, Tehran, Iran.
Kosar MoarefvandI.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
Behnam PoureslamfarDepartment of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran.
Fatemeh SameniInfectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Sajjad YazdansetadDepartment of Biology, Faculty of Basic Sciences, Imam Hossein Comprehensive University, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ferroptosis, an iron-dependent form of regulated cell death characterized by the lethal accumulation of lipid peroxides, has emerged as a pivotal pathway in cancer biology and a promising therapeutic target. This review synthesizes the core molecular machinery governing ferroptosis, detailing the critical roles of iron metabolism through systems like transferrin/transferrin receptor 1 and ferritinophagy, the cystine/glutamate antiporter system (Xc

Indexed as

Cancer therapyFerroptosisGPX4Lipid peroxidationNanoparticles

Identifiers

PMID42898245
PMCPMC13677573

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.