Evidence map›Paper›PMID 42898186›Full record

ArticleFrontiers in pharmacology2026

Spica Prunellae attenuates ER stress via GRP78/IRE1α/JNK pathway in CCL

Yanjie Wang, Jiaping Hao, Jinfeng Yang, Qiaomei Dai, Zhimin Chen, Feifei Han, Yiwen Zhang, Huijun Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yanjie WangSchool of Food and Biological Engineering, Hezhou University/Guangxi Key Laboratory of Healthcare Food Science and Technology, Hezhou, China.
Jiaping HaoSchool of Basic Medicine, Heilongjiang University of Chinese Medicine, Harbin, China.
Jinfeng YangSchool of Food and Biological Engineering, Hezhou University/Guangxi Key Laboratory of Healthcare Food Science and Technology, Hezhou, China.
Qiaomei DaiSchool of Basic Medicine, Heilongjiang University of Chinese Medicine, Harbin, China.
Zhimin ChenSchool of Basic Medicine, Heilongjiang University of Chinese Medicine, Harbin, China.
Feifei HanSchool of Materials and Chemistry, Hezhou University, Hezhou, China.
Yiwen ZhangSchool of Basic Medicine, Heilongjiang University of Chinese Medicine, Harbin, China.
Huijun ZhangSchool of Materials and Chemistry, Hezhou University, Hezhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To evaluate the effects of Spica Prunellae (SP) on CCl Methods: In the toxicity test, ICR mice were administered SP decoction (2 g/kg, crude herb/mouse weight) by gavage for 10 days. Liver and kidney tissues were collected for H&E staining, and serum levels of liver function (AST, ALT) and renal (BUN, SCR) function indicators were measured. After confirming safety, 48 ICR mice were randomly assigned to normal, model, high-, medium-, and low-dose SP, and positive control groups ( Results: SP caused minimal damage to hepatic and renal tissues in mice at 2 g/kg, with no significant changes in liver (ALT, AST) or renal (BUN, SCR) function indicators ( Conclusion: These findings suggest the involvement of the GRP78/IRE1α/JNK signaling pathway in the hepatoprotective action of SP against CCl

Indexed as

CCl4endoplasmic reticulum stressGRP78IRE1αJNKSpica Prunellae

Identifiers

PMID42898186
PMCPMC13677523

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.