Evidence map›Paper›PMID 42898181›Full record

ArticleMaterials today. Bio2026

An intrascrotal bioadhesive nanoplatform for sustained hydrogen delivery ameliorates age-associated testicular dysfunction.

Shu Liang, Jiawei Lv, Zun Li, Zheng Li, Jiachun Jiang, Shaoqing Yu, Cheng Wang, Xiongjun Wang, Lingyun Xiao, Guanzhen Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shu LiangPrecise Genome Engineering Center, School of Life Sciences, Guangzhou University, Guangzhou, 510006, China.
Jiawei LvPrecise Genome Engineering Center, School of Life Sciences, Guangzhou University, Guangzhou, 510006, China.
Zun LiPrecise Genome Engineering Center, School of Life Sciences, Guangzhou University, Guangzhou, 510006, China.
Zheng LiPrecise Genome Engineering Center, School of Life Sciences, Guangzhou University, Guangzhou, 510006, China.
Jiachun JiangPrecise Genome Engineering Center, School of Life Sciences, Guangzhou University, Guangzhou, 510006, China.
Shaoqing YuAllergy and Cancer Research Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China.
Cheng WangPrecise Genome Engineering Center, School of Life Sciences, Guangzhou University, Guangzhou, 510006, China.
Xiongjun WangPrecise Genome Engineering Center, School of Life Sciences, Guangzhou University, Guangzhou, 510006, China.
Lingyun XiaoPrecise Genome Engineering Center, School of Life Sciences, Guangzhou University, Guangzhou, 510006, China.
Guanzhen YuAllergy and Cancer Research Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Testicular aging is characterized by progressive spermatogenic decline. Accumulating oxidative injury and insufficient metabolic support from Sertoli cells may contribute to this process. Although molecular hydrogen has shown antioxidant potential, its therapeutic application in reproductive aging is limited by rapid dissipation after administration. To overcome this barrier, we developed the localized hydrogen-releasing system S-H/B. This platform integrates hydrogenated silicon nanosheets (S-H) with a bioadhesive polymer, aldehyde-functionalized polylactic acid-hyperbranched polyglycerol (PLA-HPG-al). The resulting formulation adhered to peritesticular tissue following intrascrotal injection, showed prolonged local retention, and enabled sustained hydrogen release under physiological conditions. This sustained local hydrogen delivery reduced age-associated testicular degeneration and promoted spermatogenesis in aged mice. Notably, single-cell RNA sequencing revealed enhanced HIF-1 signaling and glycolysis-related transcriptional programs in aged Sertoli cells following S-H/B treatment. Further mechanistic analyses indicated that S-H/B reduced ONOO

Indexed as

Bioadhesive nanoplatformGlycolytic reprogrammingLocalized hydrogen therapySertoli cellsTesticular aging

Identifiers

PMID42898181
PMCPMC13677336

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.