ZIF-8-gated cascade nanoreactor amplifies glucose-triggered CO release and ferroptosis for mild photothermal cancer therapy.

Haiyan Chen, Tianqing Jiang, Yibin Zhang, Ling Mei, Yujie Mao

Abstract read

In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Haiyan ChenAnti-infective Agent Creation Engineering Research Centre of Sichuan Province, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu, 610106, China.

Tianqing JiangAnti-infective Agent Creation Engineering Research Centre of Sichuan Province, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu, 610106, China.

Yibin ZhangAnti-infective Agent Creation Engineering Research Centre of Sichuan Province, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu, 610106, China.

Ling MeiAnti-infective Agent Creation Engineering Research Centre of Sichuan Province, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu, 610106, China.

Yujie MaoDepartment of Dermatology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, 32 The First Ring Road West 2, Chengdu, Sichuan, 610072, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mild photothermal therapy offers a safer alternative to conventional hyperthermia, but its therapeutic efficacy is frequently compromised by heat-shock protection, metabolic compensation and insufficient intracellular oxidative damage. Herein, we developed a ZIF-8-gated cascade nanoreactor, denoted ZIF/HMPB-CO@GOx, to amplify glucose-triggered carbon monoxide release and ferroptosis for enhanced mild photothermal cancer therapy. In this system, hollow mesoporous photothermal nanocores were loaded with a CO donor and glucose oxidase, followed by ZIF-8 coating as an acid-responsive gatekeeper. The ZIF-8 shell protected the catalytic payloads under physiological conditions and promoted intracellular release in acidic environments. Upon 808 nm laser irradiation, the nanoreactor generated nonablative mild hyperthermia and accelerated cascade reactions in which GOx catalyzed glucose oxidation to produce H

Indexed as

ATP depletionCancer therapyCarbon monoxide therapyFerroptosisGlucose oxidaseMild photothermal therapyZIF-8

Identifiers

PMID42898095

DOI10.1016/j.mtbio.2026.103724

PMCPMC13677319

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.