Evidence map›Paper›PMID 42897987›Full record

ArticlePhysiological reports2026

TRPV4/NCX1 coupling regulates Ca

Jianxin Wang, Xiongying Chen, Shuo Tong, Chengxin Qu, Wei Lu, Hui Dong

Abstract read
In one paragraph

Article in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jianxin WangDepartment of Pharmacology, School of Pharmacy, Qingdao University Medical College, Qingdao, China.
Xiongying ChenDepartment of Pediatrics, Guangyuan Central Hospital, Guangyuan, Sichuan, China.
Shuo TongDepartment of Pharmacology, School of Pharmacy, Qingdao University Medical College, Qingdao, China.
Chengxin QuDepartment of Pharmacology, School of Pharmacy, Qingdao University Medical College, Qingdao, China.
Wei LuDepartment of Pharmacology, School of Pharmacy, Qingdao University Medical College, Qingdao, China.
Hui DongDepartment of Pharmacology, School of Pharmacy, Qingdao University Medical College, Qingdao, China.ORCID https://orcid.org/0009-0000-2587-8360

Funding

National Natural Science Foundation of China 82273115National Natural Science Foundation of China 82570647
6 · The paper itself

Abstract

Although stress can stimulate the vagus nerve via the brain-gut axis to induce enterohormone secretion from enteroendocrine cells (EECs), little is currently known about the roles of ion channels in the regulation of enterohormone secretion and the development of irritable bowel syndrome (IBS). We aimed to investigate whether transient receptor potential vanilloid 4 (TRPV4) channels and Na

Indexed as

CalciumCholecystokininEnteroendocrine CellsIrritable Bowel SyndromeSodium-Calcium ExchangerTRPV Cation ChannelsAnimalsMaleMiceMice, Inbred C57BLCalciumCholecystokininSodium-Calcium Exchangersodium-calcium exchanger 1Trpv4 protein, mouseTRPV Cation Channelscholecystokininenteroendocrine cellsirritable bowel syndrome‐diarrheaNCX1TRPV4 channels

Identifiers

PMID42897987
PMCPMC13680996

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.