Evidence map›Paper›PMID 42897981›Full record

ArticleThe European journal of neuroscience2026

Aging in Autism: An Event-Related Potentials Study of Auditory Change Detection.

Marine Bessé, Shasha Morel-Kohlmeyer, Emmanuelle Houy-Durand, Philippe Prévost, Laurie Tuller, Badiâa Bouazzaoui, Laurence Taconnat, Julia Capdeville, Lucie Angel, Marie Gomot

Abstract read
In one paragraph

Article in The European journal of neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marine BesséCentre de Recherches sur la Cognition et l'Apprentissage (CeRCA), Team "Vieillissement et Psychopathologie de la Mémoire" UMR CNRS 7295, University of Tours, University of Poitiers, France.ORCID https://orcid.org/0009-0007-6069-7523
Shasha Morel-KohlmeyerUniversité de Tours, INSERM, Imaging Brain & Neuropsychiatry iBraiN U1253, Tours, France.
Emmanuelle Houy-DurandUniversité de Tours, INSERM, Imaging Brain & Neuropsychiatry iBraiN U1253, Tours, France.
Philippe PrévostUniversité de Tours, INSERM, Imaging Brain & Neuropsychiatry iBraiN U1253, Tours, France.ORCID https://orcid.org/0000-0002-6201-1800
Laurie TullerUniversité de Tours, INSERM, Imaging Brain & Neuropsychiatry iBraiN U1253, Tours, France.
Badiâa BouazzaouiCentre de Recherches sur la Cognition et l'Apprentissage (CeRCA), Team "Vieillissement et Psychopathologie de la Mémoire" UMR CNRS 7295, University of Tours, University of Poitiers, France.
Laurence TaconnatCentre de Recherches sur la Cognition et l'Apprentissage (CeRCA), Team "Vieillissement et Psychopathologie de la Mémoire" UMR CNRS 7295, University of Tours, University of Poitiers, France.
Julia CapdevilleCentre de Recherches sur la Cognition et l'Apprentissage (CeRCA), Team "Vieillissement et Psychopathologie de la Mémoire" UMR CNRS 7295, University of Tours, University of Poitiers, France.
Lucie AngelCentre de Recherches sur la Cognition et l'Apprentissage (CeRCA), Team "Vieillissement et Psychopathologie de la Mémoire" UMR CNRS 7295, University of Tours, University of Poitiers, France.
Marie GomotUniversité de Tours, INSERM, Imaging Brain & Neuropsychiatry iBraiN U1253, Tours, France.

Funding

Région Centre-Val de Loire IA-2021
6 · The paper itself

Abstract

Autistic individuals are often thought to exhibit reduced tolerance for change, which may stem from atypicalities in sensory processing, particularly in the detection of environmental changes. Within the predictive coding framework, this intolerance may reflect altered generation and updating internal predictions in response to sensory input, leading to increased prediction errors. Mismatch negativity and the P3a component are event-related potentials (ERPs) indexing automatic auditory change detection and involuntary attention shift. While studied in autistic children and young adults, little is known about how these components evolve during aging, an important gap as 21 million autistic adults over 60 are expected by 2050. This study examined mismatch negativity and P3a responses in 43 autistic adults (aged 21-64) and 60 nonautistic adults (aged 20-69) using a passive auditory oddball paradigm with standard (1000 Hz) and deviant (1100 Hz; p = 0.15) tones. Electroencephalography recording revealed no significant differences between autistic and nonautistic individuals on mismatch negativity and P3a amplitude or latency. However, mismatch negativity amplitude decreased with age over frontal site, similarly across both groups. No age-related effects were found for mismatch negativity latency or P3a measures in either group. These findings suggest that, from adulthood onward, the neural mechanisms underlying automatic change detection and preattentional processes are similar in both autistic and nonautistic adults, and that their overall time course of aging appears comparable, supporting the parallel aging hypothesis. Nonetheless, future research should explore how these preserved neural responses relate to behavioral reactivity to change in autism.

Indexed as

AgingAuditory PerceptionAutistic DisorderEvoked Potentials, AuditoryAcoustic StimulationAdultAgedElectroencephalographyFemaleHumansMaleMiddle AgedYoung Adultagingautismchange detectionmismatch negativity (MMN)P3a

Identifiers

PMID42897981
PMCPMC13680978

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.