Evidence map›Paper›PMID 42897866›Full record

ArticleBipolar disorders2026

Women With Bipolar Disorder are at Increased Risk of Sarcopenia.

Lana J Williams, Amanda L Stuart, Michael Berk, Shae E Quirk, Emma C West, Heli Koivumaa-Honkanen, Risto Honkanen, Jeremi Heikkinen, Jessica A Davis, D Kavindi Weerasinghe and 1 more

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In one paragraph

Article in Bipolar disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lana J WilliamsInstitute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, Victoria, Australia.ORCID https://orcid.org/0000-0002-1377-1272
Amanda L StuartInstitute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, Victoria, Australia.ORCID https://orcid.org/0000-0001-8770-9511
Michael BerkInstitute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, Victoria, Australia.ORCID https://orcid.org/0000-0002-5554-6946
Shae E QuirkInstitute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, Victoria, Australia.ORCID https://orcid.org/0000-0001-5375-5085
Emma C WestInstitute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, Victoria, Australia.ORCID https://orcid.org/0000-0001-9559-7003
Heli Koivumaa-HonkanenInstitute of Clinical Medicine, Psychiatry, University of Eastern Finland, Kuopio, Finland.
Risto HonkanenInstitute of Clinical Medicine, Psychiatry, University of Eastern Finland, Kuopio, Finland.
Jeremi HeikkinenInstitute of Clinical Medicine, Psychiatry, University of Eastern Finland, Kuopio, Finland.
Jessica A DavisInstitute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, Victoria, Australia.
D Kavindi WeerasingheInstitute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, Victoria, Australia.ORCID https://orcid.org/0000-0002-1050-3352
Julie A PascoInstitute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, Victoria, Australia.ORCID https://orcid.org/0000-0002-8968-4714

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWhile bipolar disorder is associated with significant comorbidity, little is known about the musculoskeletal health of individuals with bipolar disorder. Thus, we aimed to investigate the association between bipolar disorder and muscle strength, mass, quality and sarcopenia.

methodsWomen with bipolar disorder (n = 106) were recruited from healthcare settings and age-matched to controls (n = 300), without bipolar disorder, from the Geelong Osteoporosis Study. Both groups, aged ≥ 20 years. were drawn from South-Eastern Australia. Bipolar disorder was identified using a clinical interview (SCID-I/NP). Maximum handgrip strength (HGS) was measured using a Jamar dynamometer, appendicular lean mass (ALM) using a Lunar densitometer and body mass index (BMI, kg/m

resultsHigher proportion of women with bipolar disorder met criteria for low HGS and ALM compared to those without bipolar disorder. Using FNIH and EWGSOP2 criteria, 36 (8.9%; 34 probable and 2 confirmed) and 46 (11.4%; 43 probable and 3 confirmed) women met criteria for sarcopenia, respectively. Women with bipolar disorder were twice as likely to have sarcopenia (FNIH; OR 2.24, 95% CI: 1.11-4.55 and EWGSOP2; OR 2.78, 95% CI: 1.47-5.20), independent of age, smoking, activity, alcohol, diet and SES.

conclusionThese data suggest women with bipolar disorder have an increased likelihood of sarcopenia. Replication and research into underlying mechanisms are next necessary steps.

Indexed as

Bipolar DisorderSarcopeniaAdultAgedBody Mass IndexFemaleHand StrengthHumansMiddle Agedbipolar disordermental healthmuscle strengthpsychiatrysarcopenia

Identifiers

PMID42897866
PMCPMC13680794

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.