Evidence map›Paper›PMID 42897638›Full record

ArticleJournal of nanobiotechnology2026

Self-cascade oxygen-generating hydrogel/nanofibrous membrane composites restore periodontal microenvironment homeostasis.

Ye Liang, Fan Yang, Jun Kang, Zijun Chen, Ting Zou, Shaohua Ge, Chengfei Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ye LiangRestorative Dental Sciences, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China.
Fan YangRestorative Dental Sciences, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China.
Jun KangRestorative Dental Sciences, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China.
Zijun ChenRestorative Dental Sciences, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China.
Ting ZouCentral Research Laboratory, Shenzhen Stomatology Hospital (Pingshan) of Southern Medical University, Shenzhen, China.
Shaohua GeDepartment of Periodontology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, China.
Chengfei ZhangRestorative Dental Sciences, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China. zhangcf@hku.hk.

Funding

the "Chunhui Program" Cooperative Research Project HZKY20220110the SZ-HK-Macau Technology Research Programme (Type C) 2024 SGDX20230821091600004
6 · The paper itself

Abstract

The hypoxic environment of deep periodontal pockets favors the thriving of anaerobic microbes, leading to dysbiosis, tissue destruction, and treatment resistance. Elevating intra-pocket oxygen tension is a fundamental yet unmet need for controlling anaerobic pathogens in deep periodontal pockets. Our previous study demonstrated the therapeutic efficacy of oxygen-releasing hydrogel based on calcium peroxide (CPO) in reducing anaerobic pathogens in vitro. However, the rapid hydrolysis of unprotected CPO in an aqueous system and the potential oxidative damage induced by the intermediate hydrogen peroxide (H

Indexed as

HydrogelsNanofibersOxygenAnimalsBiofilmsFibroblastsFusobacterium nucleatumGingivaHomeostasisHumansHydrogen PeroxideMalePeriodontal LigamentPeriodontal PocketPeroxidesPolyesterscalcium peroxideHydrogelsHydrogen PeroxideOxygenPeroxidespolycaprolactonePolyestersBiofilmCalcium peroxideDysbiosisInfection controlInflammationPeriodontitis

Identifiers

PMID42897638
PMCPMC13681855

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.