Evidence map›Paper›PMID 42897624›Full record

ArticleCardiovascular diabetology2026

Associations between cardiac adipose tissue volume, measures of coronary calcification, myocardial microvascular function and systemic inflammation in individuals with type 2 diabetes free of overt cardiovascular disease.

Morten Steen Jensen, Ida K B Rasmussen, Anne-Cathrine Skriver-Møller, Philip Hasbak, Martin B Blond, Adam Chebli, Victor S Wasehuus, Mats C H Lassen, Morten Lindhardt, Allan Kofoed-Enevoldsen and 8 more

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Article in Cardiovascular diabetology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Morten Steen JensenSteno Diabetes Center Copenhagen, Borgmester Ib Juuls Vej 83, 2730, Herlev, Denmark.
Ida K B RasmussenSteno Diabetes Center Copenhagen, Borgmester Ib Juuls Vej 83, 2730, Herlev, Denmark.
Anne-Cathrine Skriver-MøllerSteno Diabetes Center Copenhagen, Borgmester Ib Juuls Vej 83, 2730, Herlev, Denmark.
Philip HasbakDepartment of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Martin B BlondSteno Diabetes Center Copenhagen, Borgmester Ib Juuls Vej 83, 2730, Herlev, Denmark.
Adam ChebliSteno Diabetes Center Copenhagen, Borgmester Ib Juuls Vej 83, 2730, Herlev, Denmark.
Victor S WasehuusSteno Diabetes Center Copenhagen, Borgmester Ib Juuls Vej 83, 2730, Herlev, Denmark.
Mats C H LassenDepartment of Cardiology, Herlev & Gentofte Hospital, Hellerup, Denmark.
Morten LindhardtDepartment of Internal Medicine 1, Holbæk Hospital, Holbæk, Denmark.
Allan Kofoed-EnevoldsenDepartment of Medicine, Zealand University Hospital, Nykøbing Falster, Denmark.
Urd L KielgastDepartment of Medicine, Zealand University Hospital, Køge, Denmark.
Emilie H ZobelSteno Diabetes Center Copenhagen, Borgmester Ib Juuls Vej 83, 2730, Herlev, Denmark.
Lene HolmvangDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Tor Biering-SørensenSteno Diabetes Center Copenhagen, Borgmester Ib Juuls Vej 83, 2730, Herlev, Denmark.
Peter RossingSteno Diabetes Center Copenhagen, Borgmester Ib Juuls Vej 83, 2730, Herlev, Denmark.
Rasmus S RipaDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Andreas KjaerDepartment of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Tine W HansenSteno Diabetes Center Copenhagen, Borgmester Ib Juuls Vej 83, 2730, Herlev, Denmark. tine.willum.hansen@regionh.dk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPeri- and epicardial adipose tissue (PEAT) is a metabolically active fat depot surrounding the heart and coronary arteries that may contribute to vascular dysfunction and inflammation in type 2 diabetes (T2D). We examined associations between PEAT volume, coronary calcification (CACS), myocardial flow reserve (MFR), and systemic inflammation (hsCRP).

methodsCross-sectional analysis of adults with T2D without overt CVD recruited 2020-2023. PEAT was quantified on non-contrast CT; CACS was calculated by the Agatston method; MFR was measured by rubidium-82 PET/CT; hsCRP assessed systemic inflammation. Associations were tested using multivariable regression adjusting for cardiovascular risk factors.

resultsAmong 887 participants (mean age 65 years; 70% male; mean BMI 30 kg/m

conclusionIn individuals with T2D without overt CVD, PEAT volume was not independently associated with CACS or MFR after multivariable adjustment. Higher PEAT volume was associated with higher hsCRP, suggesting a relationship with systemic inflammation; however, this exploratory finding should be interpreted in the context of established links between adiposity and inflammatory burden.

Indexed as

AdiposityCoronary Artery DiseaseDiabetes Mellitus, Type 2Epicardial Adipose TissueFractional Flow Reserve, MyocardialInflammationInflammation MediatorsMicrocirculationVascular CalcificationAgedBiomarkersC-Reactive ProteinCross-Sectional StudiesFemaleHumansMaleBiomarkersC-Reactive ProteinInflammation MediatorsCardiovascular imagingMyocardial flow reservePericardial and Epicardial adipose tisssueType 2 diabetes

Identifiers

PMID42897624
PMCPMC13682117

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.