Evidence map›Paper›PMID 42897607›Full record

ReviewBiomedical engineering online2026

Biomimetic electrospun nanofibrous composites for bone tissue engineering: a review of materials, fabrication, and applications.

N Valarmathi, S Sumathi, Helen P Kavitha, M Swaminathan, Manikandan Krishnamurthy, Manikandan Ayyar, Abdullatif Hakami, Abinet Gosaye Ayanie

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomedical engineering online, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

N ValarmathiDepartment of Chemistry, Vellore Institute of Technology, Vellore, Tamil Nadu, 632014, India.
S SumathiDepartment of Chemistry, Vellore Institute of Technology, Vellore, Tamil Nadu, 632014, India.
Helen P KavithaDepartment of Chemistry, Faculty of Engineering and Technology, SRM Institute Science and Technology, Bharathi Salai, Ramapuram, Chennai, Tamil Nadu, 600089, India.
M SwaminathanNanomaterials Laboratory, Department of Chemistry, Kalasalingam Academy of Research and Education, Krishnankoil, Tamil Nadu, 626126, India.
Manikandan KrishnamurthyDepartment of Chemistry, Faculty of Engineering and Technology, SRM Institute Science and Technology, Bharathi Salai, Ramapuram, Chennai, Tamil Nadu, 600089, India. manikank7@srmist.edu.in.
Manikandan AyyarDepartment of Chemistry, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu, 641021, India. manikandan.frsc@gmail.com.
Abdullatif HakamiDepartment of Electrical Engineering, College of Engineering, University of Bisha, P.O. Box 551, 61922, Bisha, Saudi Arabia.
Abinet Gosaye AyanieDepartment of Mechanical Engineering, Adama Science and Technology University, 2552, Adama, Ethiopia. abinet.gosaye@astu.edu.et.ORCID https://orcid.org/0009-0000-0730-0477

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A flexible and promising method for creating polymeric nanofibrous composites for BTE (bone tissue engineering) is electrospinning. The optimal composites should resemble bone's natural ECM (extracellular matrix), possess suitable surface chemistry, exhibit strong mechanical strength, and demonstrate bioactivity and biocompatibility. Selecting the appropriate material for composite fabrication is a critical initial step in developing a BTE (tissue engineered) product. BTE is a multidisciplinary area that applies engineering concepts to bone-related biological processes. Key considerations in this field include composites, cells, growth factors, and their interfaces in the microenvironment. This review article examines the recent developments in BTE using biomimetic electrospun polymeric biomaterials. It provides an overview of Natural polymer, synthetic polymer, bone structure, biocomposite discusses the ideal characteristics of bone scaffolds, and offers a basic introduction to BTE. The fabrication of bone composites is explored in detail, including various materials and techniques used. Additionally covered the characteristics, benefits, and uses of electrospinning in BTE. The application of electrospun nanofibrous composites composed of natural and synthetic polymers for BTE is thoroughly reviewed and discussed, as well as the biomineralization processes involved. Finally, the study concludes with insights into biomimetic composites for BTE based on electrospun nanofibers.

Indexed as

Biomimetic MaterialsBiomimeticsBone and BonesNanofibersTissue EngineeringAnimalsHumansPolymersTissue ScaffoldsPolymersBone tissue engineeringCompositesElectrospun nanofibrousPolymer

Identifiers

PMID42897607
PMCPMC13679161

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.