Trial reportBMC oral health2026
A randomized clinical trial comparing the effects of irrigation activation systems on postoperative pain in single-visit non-surgical endodontic retreatment.
Trial report in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07150585 (The Influence of Irrigation Activation Systems on Postoperative Pain and Periapical Lesion Healing in Single-visit Root Canal Retreatment Cases), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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The Influence of Irrigation Activation Systems on Postoperative Pain and Periapical Lesion Healing in Single-visit Root Canal Retreatment Cases: A Randomized Clinical Trial
Who cites it
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Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundThe aim of this study was to evaluate the effect of ultrasonic, sonic, and Er: YAG laser activations on postoperative pain during single-visit non-surgical endodontic retreatment of asymptomatic maxillary anterior teeth with periapical lesions following initial root canal treatment performed at least four years earlier.
methodsSeventy-five asymptomatic maxillary anterior teeth with periapical lesions following initial root canal treatment performed at least four years earlier were included. Root canal filling materials were removed using Remover rotary (Coltene MicroMega, Besançon, France) and H-type hand files and canals were reshaped with step-back technique. Final irrigation was performed with one of the activation systems: group 1: Ultra X (Eighteeth), group 2: EDDY (VDW), group 3: Er: YAG laser (LightWalker, Fotona). EDTA followed by NaOCl were activated in three cycles of 20 s in all groups. Canals were obturated with gutta-percha and BioRoot RCS and restored with composite. Pain levels were recorded using Visual analog scale (VAS) immediately after completion of treatment (0 h), and at 6, 12, 24, 48, 72 h, and on 7th day. Pearson Chi-square, Fisher's Exact, and robust mixed repeated-measures analysis of variance tests were used for statistical analysis.
resultNo flare-ups occurred, and no analgesic medication was required. The activation systems had a comparable effect on postoperative pain at any time point (p > 0.05). Postoperative pain did not exhibit any statistically significant time-dependent differences with any of the activation devices within each group.
conclusionUltrasonic, sonic, and laser-assisted irrigation activation demonstrated comparable effects on postoperative pain in asymptomatic maxillary anterior teeth undergoing single-visit non-surgical endodontic retreatment.
trial registrationThis study was registered at ClinicalTrials.gov (NCT07150585) on 29/08/2025. Retrospectively registered.
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