Evidence map›Paper›PMID 42897447›Full record

ArticleBMC microbiology2026

Prevalence and antimicrobial resistance patterns of urinary tract infections at the university hospital center in Marrakech Morocco (2020-2024): a retrospective study.

Zakaria Ellehah, Lahcen Ouahmane, Asmae Lamrani Hanchi, Nabila Soraa

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Article in BMC microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Zakaria EllehahFaculty of Sciences-Semlalia, Laboratory of Water Sciences, Microbial Biotechnologies, and Natural Resources Sustainability (AQUABIOTECH), Unit of Microbial Biotechnologies, Agrosciences, and Environment (BIOMAGE) CNRST Labeled Research Unit N°4, Cadi Ayyad University, PO Box 2390, Marrakech, 40000, Morocco. z.ellehah.ced@uca.ac.ma.
Lahcen OuahmaneFaculty of Sciences-Semlalia, Laboratory of Water Sciences, Microbial Biotechnologies, and Natural Resources Sustainability (AQUABIOTECH), Unit of Microbial Biotechnologies, Agrosciences, and Environment (BIOMAGE) CNRST Labeled Research Unit N°4, Cadi Ayyad University, PO Box 2390, Marrakech, 40000, Morocco. l.ouahmane@uca.ac.ma.
Asmae Lamrani HanchiDepartment of Microbiology, Mohamed VI University Hospital Center, Marrakech, Morocco.
Nabila SoraaDepartment of Microbiology, Mohamed VI University Hospital Center, Marrakech, Morocco.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine the prevalence, epidemiological and microbiological characteristics of urinary tract infections (UTIs), and to assess antimicrobial resistance (AMR) trends at the University Hospital Center Mohammed VI, Marrakech, over a five-year period.

methodsA retrospective cross-sectional study was conducted from January 2020 to December 2024. All urine specimens processed at the microbiology laboratory were reviewed. Duplicate isolates were excluded, and only the first positive isolate per patient per infectious episode was retained. Bacterial identification was performed using MALDI-TOF MS, and antimicrobial susceptibility testing was carried out using disk diffusion and the BD Phoenix

resultsOf 62,788 urine specimens, 8,231 were culture-positive 13.1%. Prevalence rose from 11.5% in 2020 to 14.9% in 2022, then stabilized at 12-13% in 2023-2024. Women accounted for 59.6% of cases, and patients ≥ 60 years were the most affected. Escherichia coli was the leading uropathogens 47.9%, followed by Klebsiella pneumoniae 16.7% and Enterococcus spp. 4.6%. Significant increases in resistance were observed for several clinically important antimicrobials. Amoxicillin-clavulanate resistance increased significantly in both E. coli (+ 6.00% points/year; 95% CI: 2.83-8.82; FDR-p < 0.001) and K. pneumoniae (+ 5.21% points/year; 95% CI: 2.08-8.03; FDR-p = 0.002). Ceftriaxone and piperacillin-tazobactam resistance increased significantly in E. coli, while carbapenem resistance increased significantly in both species. Fluoroquinolone resistance also showed significant upward trends in E. coli and K. pneumoniae. Among aminoglycosides, amikacin resistance increased significantly in both species, whereas gentamicin resistance increased significantly only in E. coli. No significant temporal trend was observed for trimethoprim-sulfamethoxazole resistance in either species.

conclusionUTIs remain common, with E. coli and K. pneumoniae showing increasing resistance trends, particularly against β-lactams, fluoroquinolones, carbapenems and aminoglycosides. These findings underscore the importance of ongoing surveillance and support the implementation of antimicrobial stewardship strategies.

Indexed as

Anti-Bacterial AgentsBacteriaDrug Resistance, BacterialUrinary Tract InfectionsAdolescentAdultAgedAged, 80 and overChildChild, PreschoolCross-Sectional StudiesDrug Resistance, Multiple, BacterialEscherichia coliFemaleHospitals, UniversityHumansAnti-Bacterial AgentsAntibioticsAntimicrobial resistanceMoroccoUrinary tract infections

Identifiers

PMID42897447
PMCPMC13681761

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