ArticleCurrent microbiology2026
Large-Scale Comparative Genomics of 1,374 Lactiplantibacillus plantarum Genomes Reveals an Open Pan-genome and Strain-Level Variation in Probiotic-Associated and Safety-Related Genomic Features.
Article in Current microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Lactiplantibacillus plantarum is widely studied for food fermentation and probiotic applications, but its functional and safety-related characteristics are strongly strain dependent. Large-scale comparative genomics can characterize this diversity and support genome-informed strain prioritization, although genomic evidence alone does not establish probiotic efficacy or safety. A RefSeq genome collection of L. plantarum was subjected to accession-level auditing, exact-sequence dereplication, and predefined genome-quality filtering, yielding 1,374 unique genomes for final analysis. Genome characteristics, pan-genome structure, probiotic-associated annotation proxies, targeted sequence evidence, predefined safety-related genomic markers, isolation-source metadata, and COG functional annotations were evaluated. The final cohort had a mean genome size of 3.286 ± 0.126 Mb and a mean GC content of 44.419 ± 0.168%. Genome size and GC content showed a negative dataset-level association (Pearson's r = - 0.767; R
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