Evidence map›Paper›PMID 42897302›Full record

ArticleNature neuroscience2026

Spatiotemporal remodeling in habenula marks the onset of depression-related phenotypes.

Patricia Molina, Denys Osypenko, Josep Garnica, Quentin Amossé, Farha Bouteldja, Léa Camelot, Sarah Mondoloni, Mauro Congiu, Claudia Kathe, Manuel Mameli

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Article in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Patricia MolinaDepartment of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-4118-4702
Denys OsypenkoDepartment of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-7588-9201
Josep GarnicaDepartment of Oncology, Ludwig Institute for Cancer Research, Lausanne Branch, CHUV and University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-9493-1321
Quentin AmosséDepartment of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-5553-9594
Farha BouteldjaDepartment of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland.
Léa CamelotDepartment of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland.
Sarah MondoloniDepartment of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland.
Mauro CongiuDepartment of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland.
Claudia KatheDepartment of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-6441-1755
Manuel MameliDepartment of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland. manuel.mameli@unil.ch.ORCID http://orcid.org/0000-0002-0570-6964

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 310030_212193
6 · The paper itself

Abstract

Chronic stress has lasting adverse consequences that can lead, over time, to depression, yet the optimal timeframe for effective therapies remains unclear. The lateral habenula (LHb) has been implicated in stress-related behavioral repercussions, but the precise timing of its contribution is not understood. Here, using spatial transcriptomics, we generated a spatially resolved molecular atlas of the LHb of male mice, revealing a topographically organized and temporally defined remodeling of gene expression after chronic stress. Longitudinal in vivo two-photon calcium imaging of individual LHb neurons revealed progressively heightened excitatory responses to aversive stimuli. These neuronal adaptations mirrored both the progression of transcriptional changes and the emergence of depression-related behavioral phenotypes and were reversed by the antidepressant ketamine. Moreover, chemogenetically limiting LHb neuronal activity or administering ketamine at the onset of these changes exerted antidepressant effects. These findings link spatiotemporal signatures of LHb neuronal ensembles and genetic landscape with the onset of stress-induced depression-related states.

Identifiers

PMID42897302

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.