ArticleSkeletal radiology2026
Perfusion characterization of osteosarcoma spinal metastases using advanced T1-weighted dynamic contrast enhanced MRI.
Article in Skeletal radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveSpinal osteosarcoma is rare and highly aggressive malignancy associated with poor clinical outcomes. To our knowledge, the perfusion MRI features of spinal osteosarcoma using T1-weighted DCE MRI, including plasma volume, permeability, and time-intensity analysis, have not previously been studied. In addition, changes in these features following radiation treatment have not yet been evaluated. We hypothesize that highly malignant spinal osteosarcoma demonstrates hypervascularity based on its pharmacokinetic perfusion parameters. MATERIALS AND
methodsWe analyzed 27 patients (mean age 44.5, SD 21.8) of untreated metastatic Spinal osteosarcoma who underwent DCE-MRI. Perfusion parameters, including K
resultsThirty-five lesions in 27 patients were evaluated. Perfusion characteristics including mean K
conclusionDCE-MRI evaluation of metastatic Spinal osteosarcoma demonstrates a rich blood supply, consistent with hypervascular metastatic disease. Changes in the time intensity curve analysis may serve as non-invasive marker of radiation treatment response.
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