Evidence map›Paper›PMID 42897266›Full record

ArticleNature cell biology2026

Monocyte surface Y RNAs potentiate innate immunity.

Xiao Jiang, Weizhi He, Chu Xu, Wanwei Zheng, Chenye Li, Danhua Xu, Qixin Shao, Yin Li, Zhuo Liu, Wenshuai Li and 9 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Xiao Jiang *Cancer Institute, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Key Laboratory of Medical Epigenetics, International Laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Weizhi He *Cancer Institute, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Key Laboratory of Medical Epigenetics, International Laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Chu Xu *Cancer Institute, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Key Laboratory of Medical Epigenetics, International Laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Wanwei Zheng *Sycamore Research Institute of Life Sciences, Shanghai, China.
Chenye LiSycamore Research Institute of Life Sciences, Shanghai, China.
Danhua XuDepartment of Digestive Diseases, and National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Qixin ShaoCancer Institute, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Key Laboratory of Medical Epigenetics, International Laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Yin LiCancer Institute, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Key Laboratory of Medical Epigenetics, International Laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Zhuo LiuCancer Institute, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Key Laboratory of Medical Epigenetics, International Laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Wenshuai LiSycamore Research Institute of Life Sciences, Shanghai, China.
Shuang HeCancer Institute, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Key Laboratory of Medical Epigenetics, International Laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Zhiqiang WangShanghai Xuhui Central Hospital, Zhongshan-Xuhui Hospital, and the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Ronghua LiuShanghai Xuhui Central Hospital, Zhongshan-Xuhui Hospital, and the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Yiwei ChuInstitutes of Biomedical Sciences, Fudan University, Shanghai, China.
Zhongguang LuoSycamore Research Institute of Life Sciences, Shanghai, China. luozg@fudan.edu.com.
Xinxin HuangDepartment of Digestive Diseases, and National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China. xinxinhuang@fudan.edu.cn.ORCID http://orcid.org/0000-0002-4298-4859
Jie LiuSycamore Research Institute of Life Sciences, Shanghai, China. jieliu@fudan.edu.cn.ORCID http://orcid.org/0000-0002-7638-187X
Enzhuo YangCancer Institute, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Key Laboratory of Medical Epigenetics, International Laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China. yangenzhuo@126.com.ORCID http://orcid.org/0000-0001-9131-482X
Lulu HuCancer Institute, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Key Laboratory of Medical Epigenetics, International Laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China. luluhu@fudan.edu.cn.ORCID http://orcid.org/0000-0001-7246-1736

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RNAs can associate with the surface of diverse cell types, yet the functions of specific RNA species on primary immune cells remain unclear. Here, utilizing methods developed to profile, image and quantify surface RNAs in rare primary cell populations, we found that Y RNAs, a family of small noncoding RNAs, preferentially localize to human monocyte surface. In an exploratory pooled inflammatory bowel disease cohort, the proportion of cell-surface-Y-RNA-positive peripheral monocytes was markedly higher in patients with inflammatory bowel disease than in healthy donors or individuals with irritable bowel syndrome. In vivo depletion of cell-surface Y RNAs ameliorates disease activity in mice with colitis. Mechanistically, cell-surface Y RNAs co-cluster with Toll-like receptors TLR2 and TLR4, bind extracellular histones and promote receptor-mediated histone recognition, thereby activating NF-κB and AP-1 signalling and increasing IL6 expression and IL-6 secretion. These findings identify cell-surface Y RNAs as previously unrecognized amplifiers of inflammatory activation.

Identifiers

PMID42897266

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.