Evidence map›Paper›PMID 42897207›Full record

ArticleNature communications2026

Nano-kinetic implant surface mediates osteo-antibacterial synergy through electromagnetic-mechanical coupling.

Yangmengfan Chen, Hao Du, Heng Sun, Xingcan Huang, Duan Wang, Xuming Chen, Jiehao Chen, Xuanjun Zhang, Liqiang Zhou, Zongke Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yangmengfan ChenDepartment of Orthopedics and Research Institute of Orthopedics, West China Hospital, Sichuan University, Chengdu, China.
Hao DuDepartment of Orthopedics and Research Institute of Orthopedics, West China Hospital, Sichuan University, Chengdu, China.
Heng SunFaculty of Medicine, University of Macau, Macau SAR, China.
Xingcan HuangSchool of Biomedical Engineering, Cheeloo College of Medicine, Shandong University, Jinan, China.
Duan WangDepartment of Orthopedics and Research Institute of Orthopedics, West China Hospital, Sichuan University, Chengdu, China.
Xuming ChenDepartment of Orthopedics and Research Institute of Orthopedics, West China Hospital, Sichuan University, Chengdu, China.
Jiehao ChenAnimal Experimental Center, West China Hospital, Sichuan University, Chengdu, China.
Xuanjun ZhangFaculty of Medicine, University of Macau, Macau SAR, China.ORCID 0000-0001-6452-1778
Liqiang ZhouFaculty of Medicine, University of Macau, Macau SAR, China. liqiangzhou@um.edu.mo.ORCID 0000-0002-1184-4036
Zongke ZhouDepartment of Orthopedics and Research Institute of Orthopedics, West China Hospital, Sichuan University, Chengdu, China. zhouzongke@scu.edu.cn.ORCID 0000-0002-9037-4756

Funding

Fundo para o Desenvolvimento das Ciências e da Tecnologia (Science and Technology Development Fund) 0032/2023/ITP1National Natural Science Foundation of China (National Science Foundation of China) 82302369
6 · The paper itself

Abstract

Periprosthetic joint infection (PJI) is a devastating complication of total joint arthroplasty, mainly caused by bacterial biofilm formation and antibiotic resistance. Traditional static surfaces rely on contact killing-based bactericidal properties and cannot reliably clear mature biofilms. In this study, we fabricate a remote-activated dynamic biomimetic system, namely a movable magnetic topographic surface (MMTS). Here we show that under the exposure of external electromagnetic field (EMF), the anchored Janus nano-heterodimers oscillate periodically to mechanically disrupt bacterial membranes and eradicates biofilms of Staphylococcus aureus and Escherichia coli. This mechanical force can also activates Piezo1 mechanosensitive ion channel in bone marrow mesenchymal stem cells (BMSCs), inducing calcium oscillations, upregulating gene expression of Runx2 and BMP2, and enhancing extracellular matrix mineralization. In vivo, MMTS combined with EMF exposure eliminates local infection and promoted osseointegration. This remote-activated dynamic biomimetic strategy offers a promising multifunctional platform for PJI treatment, and improved implant osteointegration in clinical orthopedics.

Indexed as

Anti-Bacterial AgentsProstheses and ImplantsProsthesis-Related InfectionsAnimalsBiofilmsBone Morphogenetic Protein 2Core Binding Factor Alpha 1 SubunitElectromagnetic FieldsEscherichia coliHumansIon ChannelsMesenchymal Stem CellsMiceOsseointegrationStaphylococcus aureusSurface PropertiesAnti-Bacterial AgentsBone Morphogenetic Protein 2Core Binding Factor Alpha 1 SubunitIon ChannelsRunx2 protein, mouse

Identifiers

PMID42897207
PMCPMC13680427

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.