Evidence map›Paper›PMID 42897204›Full record

ArticleCellular & molecular immunology2026

Dysregulated thymus-ovary axis promotes virtual memory T cell polarization to aggravate PMOS pathology.

Yaruo Qiu, Huiyu Xu, Wenyu Tian, Weixuan Wang, Chenlei Xu, Yao Feng, Xuyang Zhao, Wen Gao, Rong Jin, Rong Li and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Cellular & molecular immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yaruo Qiu *Institute of Systems Biomedicine, Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory of Advanced Pharmaceutical Preparation, Peking University, Beijing, 100191, China.
Huiyu Xu *State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, 100191, China.
Wenyu Tian *Institute of Systems Biomedicine, Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory of Advanced Pharmaceutical Preparation, Peking University, Beijing, 100191, China.
Weixuan WangInstitute of Systems Biomedicine, Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory of Advanced Pharmaceutical Preparation, Peking University, Beijing, 100191, China.
Chenlei XuInstitute of Systems Biomedicine, Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory of Advanced Pharmaceutical Preparation, Peking University, Beijing, 100191, China.
Yao FengInstitute of Systems Biomedicine, Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory of Advanced Pharmaceutical Preparation, Peking University, Beijing, 100191, China.
Xuyang ZhaoInstitute of Systems Biomedicine, Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory of Advanced Pharmaceutical Preparation, Peking University, Beijing, 100191, China.ORCID http://orcid.org/0000-0002-4470-7986
Wen GaoDepartment II of Liver Diseases, Beijing You'an Hospital, Affiliated with Capital Medical University, Beijing, 100069, China.
Rong JinInstitute of Systems Biomedicine, Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory of Advanced Pharmaceutical Preparation, Peking University, Beijing, 100191, China. jinrong@bjmu.edu.cn.
Rong LiState Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, 100191, China. roseli001@sina.com.
Dan LuInstitute of Systems Biomedicine, Department of Immunology, School of Basic Medical Sciences, Beijing Key Laboratory of Advanced Pharmaceutical Preparation, Peking University, Beijing, 100191, China. taotao@bjmu.edu.cn.ORCID http://orcid.org/0000-0002-3000-5094

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32571053National Natural Science Foundation of China (National Science Foundation of China) 82541009Natural Science Foundation of Beijing Municipality (Beijing Natural Science Foundation) F252067
6 · The paper itself

Abstract

Polyendocrine metabolic ovarian syndrome (PMOS) is traditionally attributed to dysfunction of the hypothalamic-pituitary-gonadal axis, but the contribution of extra-reproductive organs remains unclear. Here, we identify a thymus-ovary pathway linking androgen excess to ovarian inflammation. Androgen receptor signaling in thymic stromal cells induces early thymic involution and impairs thymic output before overt reproductive pathology emerges. Athymic mice and Rag1

Indexed as

JAK inhibitionPMOSThymus‒ovary axisVirtual memory CD8+ T cells

Identifiers

PMID42897204

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.