ArticleNature communications2026
Microglia and border-associated macrophages play opposite roles in cerebrovascular and leukocyte responses under systemic inflammation in male mice.
Ana Rita Brás, Nikolett Lénárt, Damien Levard, Martina Glavan, Ákos Menyhárt, Csaba Cserép, Balázs Pósfai, Eszter Császár, Sai K Reddy Samawar, Clare Pridans and 5 more
Abstract read
In one paragraphArticle in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
15 authors.
Ana Rita Brás *"Momentum" Laboratory of Neuroimmunology, HUN-REN Institute of Experimental Medicine, Budapest, Hungary.ORCID 0000-0003-4319-7010 Nikolett Lénárt *"Momentum" Laboratory of Neuroimmunology, HUN-REN Institute of Experimental Medicine, Budapest, Hungary.ORCID 0000-0002-7456-949X Damien LevardNormandie University, Caen Normandie University, UNICAEN, INSERM U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Cyceron, Institut Blood and Brain @ Caen-Normandie (BB@C), Caen, France.ORCID 0000-0002-7275-3170 Martina GlavanNormandie University, Caen Normandie University, UNICAEN, INSERM U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Cyceron, Institut Blood and Brain @ Caen-Normandie (BB@C), Caen, France.
Ákos MenyhártHungarian Centre of Excellence for Molecular Medicine - University of Szeged, Cerebral Blood Flow and Metabolism Research Group, Szeged, Hungary.
Csaba Cserép"Momentum" Laboratory of Neuroimmunology, HUN-REN Institute of Experimental Medicine, Budapest, Hungary.
Balázs Pósfai"Momentum" Laboratory of Neuroimmunology, HUN-REN Institute of Experimental Medicine, Budapest, Hungary.ORCID 0000-0003-1035-565X Eszter Császár"Momentum" Laboratory of Neuroimmunology, HUN-REN Institute of Experimental Medicine, Budapest, Hungary.
Sai K Reddy SamawarInstitute of Physiological Chemistry and Pathobiochemistry, University of Muenster, Munster, Germany.
Clare PridansCentre for Inflammation Research Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-9423-557X Denis VivienNormandie University, Caen Normandie University, UNICAEN, INSERM U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Cyceron, Institut Blood and Brain @ Caen-Normandie (BB@C), Caen, France.ORCID 0000-0002-7636-2185 Eszter FarkasHungarian Centre of Excellence for Molecular Medicine - University of Szeged, Cerebral Blood Flow and Metabolism Research Group, Szeged, Hungary.ORCID 0000-0002-8478-9664 Lydia SorokinInstitute of Physiological Chemistry and Pathobiochemistry, University of Muenster, Munster, Germany.ORCID 0000-0001-7704-7921 Marina RubioNormandie University, Caen Normandie University, UNICAEN, INSERM U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Cyceron, Institut Blood and Brain @ Caen-Normandie (BB@C), Caen, France.ORCID 0000-0002-6120-4053 Ádám Dénes"Momentum" Laboratory of Neuroimmunology, HUN-REN Institute of Experimental Medicine, Budapest, Hungary. denes.adam@koki.hun-ren.hu.ORCID 0000-0001-6919-4905 Funding
ERA-NET 2024 MeniSPYsERC-2021-ADG 101054805 - B3MNEuropean Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant “ENTRAIN” 813294Hungarian Brain Research Program KTIA_13_NAP-A-I/ 2“Momentum” Program of the Hungarian Academy of Sciences LP2016- 4/2016National Research, Development and Innovation Office of Hungary (NKFIH STARTING_24) 150356 AND FK142218
6 · The paper itselfAbstract
Microglia closely associate with the vasculature, but their roles in leukocyte trafficking and cerebral blood flow (CBF) during systemic inflammation are unclear. We show that sustained systemic inflammation leads to altered microglia-vascular interactions, leukocyte recruitment to cerebral blood vessels and reduced hypercapnia-induced vasodilation. We find that microglia and border-associated macrophages (BAMs) play distinct roles in these processes: while BAM depletion with clodronate increases leukocyte recruitment, microglia/BAM depletion with PLX5622 and the absence of microglia, but not BAMs in CSF1R
Indexed as
Cerebrovascular CirculationInflammationLeukocytesMacrophagesMicrogliaAnimalsBrainClodronic AcidHypercapniaInterleukin-1alphaMaleMiceMice, Inbred C57BLMice, KnockoutOrganic ChemicalsReceptors, Granulocyte-Macrophage Colony-Stimulating FactorClodronic AcidCsf1r protein, mouseIl1a protein, mouseIL1R1 protein, mouseInterleukin-1alphaOrganic ChemicalsPLX5622Receptors, Granulocyte-Macrophage Colony-Stimulating FactorReceptors, Interleukin-1 Type I
Identifiers
PMID42897171
PMCPMC13680361
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