ArticleNature communications2026
Genome-directed discovery of an octalin-containing polyether ionophore improves diabetic skin wound healing.
Chunyan Fang, Zhiwen Liu, Liangliang Bai, Liang Ma, Weiliang Xiong, Lili Sun, Linping Wu, Jing Ni, Wenjun Zhang, Yiguang Zhu and 3 more
Abstract read
In one paragraphArticle in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
13 authors.
Chunyan Fang *State Key Laboratory of Tropical Oceanography, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China.ORCID 0000-0002-3386-2331 Zhiwen Liu *State Key Laboratory of Tropical Oceanography, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China.
Liangliang Bai *Department of Pharmacy, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Liang MaState Key Laboratory of Tropical Oceanography, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China.
Weiliang XiongState Key Laboratory of Tropical Oceanography, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China.
Lili SunState Key Laboratory of Tropical Oceanography, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China.
Linping WuChina-New Zealand Joint Laboratory on Biomedicine and Health, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.ORCID 0000-0001-7579-2987 Jing NiChina-New Zealand Joint Laboratory on Biomedicine and Health, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
Wenjun ZhangState Key Laboratory of Tropical Oceanography, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China.
Yiguang ZhuState Key Laboratory of Tropical Oceanography, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China.
Yanxin LuoDepartment of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. luoyx25@mail.sysu.edu.cn.ORCID 0000-0002-5200-3997 Yingjie LiChina-New Zealand Joint Laboratory on Biomedicine and Health, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China. li_yingjie@gibh.ac.cn.ORCID 0000-0003-3386-0210 Changsheng ZhangState Key Laboratory of Tropical Oceanography, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China. czhang2006@gmail.com.ORCID 0000-0003-2349-3138 Funding
China Postdoctoral Science Foundation GZC20250585 and 2025M770863
6 · The paper itselfAbstract
Chronic hard-to-heal skin wounds in diabetes mellitus pose a significant clinical challenge, underscoring the urgent need for additional therapeutics. Herein, we report the identification of a polyether biosynthetic gene cluster (pdm BGC) from the marine-derived Streptomyces marincola SCSIO 03032 through genome mining. By overexpressing the positive regulator gene pdmRI, we increase the product of the pdm BGC 48-fold to enable the isolation, structural determination, and biosynthesis investigation of an octalin-containing polyether ionophore polydecalinmycin (PDM). Functionally, PDM demonstrates remarkable efficacy in promoting acute skin wound healing in BALB/c mice and significantly accelerating chronic wound closure in a diabetic mouse (db/db, male) model. Mechanistically, PDM induces an elevation of mitochondrial Na
Indexed as
Diabetes Mellitus, ExperimentalIonophoresSkinWound HealingAnimalsHumansMaleMiceMice, Inbred BALB CMitochondriaMultigene FamilyNF-E2-Related Factor 2Oxidative StressPolyether CompoundsReactive Oxygen SpeciesStreptomycesIonophoresNF-E2-Related Factor 2Polyether CompoundsReactive Oxygen Species
Identifiers
PMID42897161
PMCPMC13680505
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