Evidence map›Paper›PMID 42897156›Full record

ArticleNature communications2026

Development-inspired approach for the derivation of functional and transplantable salivary gland organoids from human pluripotent stem cells.

Laura J Sherwood, Ronel Z Samuel, Sai Harsha Bhamidipati, Kihoon Nam, Frank Maslow, Travis Small, Yali Zhang, Jianmin Wang, Song Liu, Olga J Baker and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Laura J Sherwood *Department of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY, USA.
Ronel Z Samuel *Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY, USA.ORCID 0009-0005-0164-2114
Sai Harsha BhamidipatiDepartment of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY, USA.ORCID 0009-0004-7671-0954
Kihoon NamBond Life Sciences Center, University of Missouri, Columbia, MO, USA.
Frank MaslowBond Life Sciences Center, University of Missouri, Columbia, MO, USA.
Travis SmallBond Life Sciences Center, University of Missouri, Columbia, MO, USA.
Yali ZhangDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Jianmin WangDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.ORCID 0000-0001-7527-0409
Song LiuDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Olga J BakerBond Life Sciences Center, University of Missouri, Columbia, MO, USA.ORCID 0000-0002-0628-8645
Stelios T AndreadisDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY, USA. sandread@buffalo.edu.ORCID 0000-0001-9885-0457

Funding

THE USE OF FIBRIN HYDROGELS TO PROMOTE SALIVARY GLAND REGENERATIONR01DE022971 · NIDCR · UNIVERSITY OF UTAH · PI ANDREADIS, STELIOS T., BAKER, OLGA JULIANA · 2012 to 2025
$7.2M
Advanced Training in Oral BiologyT32DE023526 · NIDCR · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Stefan Hans-Klaus Ruhl · 2013 to 2026
$3.7M
NIDCR NIH HHS R01 DE022971NIDCR NIH HHS T32 DE023526U.S. Department of Health & Human Services | NIH | National Institute of Dental and Craniofacial Research (NIDCR) DE023526U.S. Department of Health & Human Services | NIH | National Institute of Dental and Craniofacial Research (NIDCR) DE03431001U.S. Department of Health & Human Services | NIH | National Institute of Dental and Craniofacial Research (NIDCR) R01DE022971-12
6 · The paper itself

Abstract

Salivary gland (SG) hypofunction significantly affects the life quality of patients with hyposalivation. Current treatment options for these conditions are limited and often result in undesirable side effects. To address this issue, we've developed a developmentally inspired strategy to derive salivary gland epithelial progenitor (SGEP) cells from human pluripotent stem cells (PSC). Then we employ SGEP cells derived from human PSC with a SOX10::GFP reporter to engineer three-dimensional lumenized SG organoids, with well-defined lumens and secretory function, reminiscent of human salivary glands. Upon transplantation into the submandibular gland of athymic nude mice, mCherry+ salivary gland organoids (SGO) integrate into the gland and differentiated into salivary gland phenotypes, including acinar, ductal and myoepithelial structures. Our findings suggest that SG organoids may hold promise for studying SG development, disease progression and drug screening, as well as for development of cell therapies for salivary gland regeneration.

Indexed as

OrganoidsPluripotent Stem CellsSalivary GlandsAnimalsCell DifferentiationEpithelial CellsHumansMiceMice, Nude

Identifiers

PMID42897156
PMCPMC13680624

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.