Trial report in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02977442 (Dynamics of Muscle Mitochondria in Type 2 Diabetes), which is not on this map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dynamics of Muscle Mitochondria in Type 2 Diabetes
TypeinterventionalSponsorPennington Biomedical Research CenterRan2016 to 2025Enrolled24ConditionsInsulin Resistance, DiabetesArmsexercise
3 · Its place in the literature
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The record
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
14 authors.
Elizabeth C HeintzPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.
Wagner S DantasPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.ORCID 0000-0003-4561-4930
Analisa L TaylorPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.
Elizabeth R M ZunicaPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.ORCID 0000-0002-6850-6054
Kathryn P BelmontPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.ORCID 0000-0003-2658-1459
Jackson M SlonePennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.
Jacob T MeyPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.ORCID 0000-0001-6826-7762
Robbie BeylPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.
Bolormaa VandanmagsarPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.
Hailey A ParryNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Peter AjayiNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-2378-5758
Brian GlancyNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-8571-244X
Christopher L AxelrodPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA. christopher-axelrod@ou.edu.ORCID 0000-0002-1444-8557
John P KirwanPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA. john-kirwan@ou.edu.ORCID 0000-0001-7321-9917
Funding
Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1M
Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2005 to 2026
$26.5M
Understanding the relationship between obesity and tongue fat in humans and ratsP01HL094307 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI SCHWAB, RICHARD J. · 2009 to 2020
$23.7M
The role of maternal obesity-driven inflammation and adverse pregnancy outcomes in a mouse model of preeclampsiaP20GM135002 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Jacob T Mey · 2020 to 2026
$18.4M
Training in Botanical Approaches to Combat Metabolic SyndromeT32AT004094 · NCCIH · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI BRANTLEY, PHILLIP J, STEPHENS, JACQUELINE M · 2009 to 2024
$5.7M
Role and Regulation of Skeletal Muscle Mitochondrial Dynamics in Type 2 DiabetesR01DK108089 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI JOHN P. KIRWAN · 2015 to 2026
$4.9M
The Role of Nuclear Factor Erythroid 2-related factor 2 in Sarcopenic ObesityR00AG083239 · NIA · UNIVERSITY OF OREGON · PI Wagner Silva Dantas · 2025 to 2026
$493k
Individualized Nutrition to Help Asthmatics Improve Lung Function and Energetics (INHALE)K01HL169491 · NHLBI · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI MEY, JACOB T · 2023 to 2024
$283k
Hepatic SLC25a25 in Steatotic Liver Disease ProgressionF31DK139728 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Elizabeth C Heintz · 2024 to 2026
$129k
The Role of Nuclear Factor Erythroid 2-related factor 2 in Sarcopenic ObesityK99AG083239 · NIA · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI DANTAS, WAGNER SILVA · 2024 to 2024
Imbalanced skeletal muscle mitochondrial dynamics contribute to the onset and progression of type 2 diabetes (T2D) by mechanisms that remain incompletely understood. Here, we examined the role of Mitochondrial Rho GTPase 1 (Miro1), an outer mitochondrial membrane enzyme, in regulating skeletal muscle insulin action and glucose homeostasis in type 2 diabetes (T2D). In a cross-sectional clinical study, we show that Miro1 accumulates in the skeletal muscle of patients with obesity and T2D, which was further replicated in mouse models of T2D. This accumulation is explained by inadequate insulin-mediated interaction between AKT and Miro1 at the outer mitochondrial membrane. In a randomized controlled trial (NCT02977442), we show that exercise training relieves skeletal muscle Miro1 accumulation while improving insulin sensitivity in patients with T2D. Muscle-specific Miro1 deletion improves oxidative capacity and insulin sensitivity in mice and cells. Taken together, these data support a key regulatory role for skeletal muscle Miro1 in the pathophysiology of T2D. ClinicalTrials.gov Identifier: NCT02977442.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Miro1 mediates skeletal muscle insulin resistance in type 2 diabetes. · full record | OpenQuestion