Evidence map›Paper›PMID 42897004›Full record

ReviewZhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery2026

[Advances in biodegradable medical magnesium alloys for orthopedic applications].

Xingyu Shan, Hongda Wang, Jialong Lu, Zili Feng, Huanxi Li, Zhimin Tian, Kaipeng Zhuang, Shenghu Zhou, Haoqiang Zhang

Abstract readReviewEnglish Abstract
In one paragraph

Review in Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xingyu ShanFirst Clinical Medical College, Gansu University of Chinese Medicine, Lanzhou Gansu, 730000, P. R. China.
Hongda WangFirst Clinical Medical College, Gansu University of Chinese Medicine, Lanzhou Gansu, 730000, P. R. China.
Jialong LuFirst Clinical Medical College, Gansu University of Chinese Medicine, Lanzhou Gansu, 730000, P. R. China.
Zili FengDepartment of Joint Surgery, the 940th Hospital of Joint Logistics Support Force of the Chinese PLA, Lanzhou Gansu, 730000, P. R. China.
Huanxi LiFirst Clinical Medical College, Gansu University of Chinese Medicine, Lanzhou Gansu, 730000, P. R. China.
Zhimin TianDepartment of Joint Surgery, the 940th Hospital of Joint Logistics Support Force of the Chinese PLA, Lanzhou Gansu, 730000, P. R. China.
Kaipeng ZhuangDepartment of Joint Surgery, the 940th Hospital of Joint Logistics Support Force of the Chinese PLA, Lanzhou Gansu, 730000, P. R. China.
Shenghu ZhouDepartment of Joint Surgery, the 940th Hospital of Joint Logistics Support Force of the Chinese PLA, Lanzhou Gansu, 730000, P. R. China.
Haoqiang ZhangFirst Clinical Medical College, Gansu University of Chinese Medicine, Lanzhou Gansu, 730000, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To systematically review the current research status of biodegradable medical magnesium alloys as orthopedic implant materials, clarify key advances in composition design, fabrication processing, surface modification, and biological mechanisms, and identify the major scientific questions and engineering challenges in clinical translation, thus providing a theoretical foundation for future product development and clinical application. Methods: The literature on magnesium alloy implants both domestically and internationally in recent years was extensively reviewed, with a particular focus on alloying strategies, advanced fabrication techniques, and surface modification processes and their effects on corrosion behavior and bioactivity, as well as the molecular evidence of magnesium ion (Mg Results: Alloy design and process optimization significantly improve the mechanical properties and degradation controllability of magnesium alloys, while surface modification effectively retards initial corrosion and enhances biocompatibility. Biological studies confirm that Mg Conclusion: Biodegradable magnesium alloys hold considerable promise for orthopedic implantation; however, precise matching of degradation kinetics with bone healing timelines, rigorous evaluation of long-term biosafety, and customization for patient-specific applications remain the primary bottlenecks hampering widespread clinical translation. Future efforts should integrate materials engineering, biological sciences, and digital manufacturing technologies to advance intelligent, personalized therapeutic strategies.

Indexed as

Absorbable ImplantsAlloysBiocompatible MaterialsMagnesiumAnimalsCorrosionHumansOsteogenesisSurface PropertiesAlloysBiocompatible MaterialsMagnesiumbiocompatibilityBiodegradable medical magnesium alloyclinical translationorthopedic implantosteogenic mechanismsurface modification

Identifiers

PMID42897004
PMCPMC13677480

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.