Evidence map›Paper›PMID 42896099›Full record

ArticleEmerging microbes & infections2026

Fas receptor binding is a key determinant of the enhanced aggressiveness of the novel recombinant Echovirus 11.

Leonardo Sclavi, Giulia Venneri, Antonella Bugatti, Marta Giovanetti, Serena Messali, Cheryl L Maier, Guido Silvestri, Francesca Caccuri, Arnaldo Caruso

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Emerging microbes & infections, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Leonardo SclaviDivision of Microbiology and Immunology, Emory Vaccine Centre, Emory National Primate Research Centre, Emory University, Atlanta, USA.
Giulia VenneriSection of Microbiology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Antonella BugattiSection of Microbiology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Marta GiovanettiDepartment of Science and Bio-Technology, Università Campus Bio-Medico di Roma, Roma, Italy.
Serena MessaliSection of Microbiology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Cheryl L MaierDepartment of Pathology and Laboratory Medicine, Emory University, Atlanta, USA.
Guido SilvestriDivision of Microbiology and Immunology, Emory Vaccine Centre, Emory National Primate Research Centre, Emory University, Atlanta, USA.
Francesca CaccuriSection of Microbiology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Arnaldo CarusoSection of Microbiology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel recombinant strain of Echovirus 11 has recently emerged worldwide and has been associated with increased pathogenicity, particularly causing severe disease in neonates. The enhanced virulence of this variant may be linked to its recombinant nature and the accumulation of mutations in capsid proteins.In this study, we investigated the relationship between genetic variations and virulence using a clinical isolate of the dominant Echovirus 11 D5 genotype, in comparison with the prototype strain.

Indexed as

Echovirus InfectionsEnterovirus B, Humanfas ReceptorA549 CellsAnimalsCapsid ProteinsGenotypeHumansProtein BindingRecombination, GeneticVirulenceVirus ReplicationCapsid Proteinsfas ReceptorapoptosisEchovirus 11enterovirusFas receptorrecombinant strain

Identifiers

PMID42896099
PMCPMC13686198

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.