Evidence map›Paper›PMID 42895991›Full record

ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2026

Cationic Tantalum Oxide Nanoparticle and Neutral Iodixanol Contrast Agents Alter Cartilage Mechanical Properties.

Maria Rissanen, Jiri Jäntti, Juuso Tuppurainen, Milka Poimala, Brian D Snyder, Mark W Grinstaff, Mika E Mononen, Miitu K M Honkanen, Janne T A Mäkelä

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Maria RissanenDepartment of Technical Physics, University of Eastern Finland, Kuopio, Finland.ORCID https://orcid.org/0009-0001-3427-7679
Jiri JänttiDepartment of Technical Physics, University of Eastern Finland, Kuopio, Finland.ORCID https://orcid.org/0000-0001-8442-8458
Juuso TuppurainenDepartment of Technical Physics, University of Eastern Finland, Kuopio, Finland.ORCID https://orcid.org/0000-0001-9724-3903
Milka PoimalaDepartment of Technical Physics, University of Eastern Finland, Kuopio, Finland.ORCID https://orcid.org/0009-0000-5779-1307
Brian D SnyderBoston Children's Hospital, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0003-1482-9509
Mark W GrinstaffDepartments of Biomedical Engineering, Chemistry, and Medicine, Boston University, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-5453-3668
Mika E MononenDepartment of Technical Physics, University of Eastern Finland, Kuopio, Finland.
Miitu K M HonkanenCenter of Oncology, Kuopio University Hospital, Wellbeing Services County of North Savo, Kuopio, Finland.
Janne T A MäkeläDepartment of Technical Physics, University of Eastern Finland, Kuopio, Finland.ORCID https://orcid.org/0000-0002-6123-1262

Funding

Biocenter KuopioResearch council of Finland 348410Research council of Finland 352666Research council of Finland 357787Research council of Finland 372127State Research Funding for university-level health research of the Kuopio University Hospital 5041810State Research Funding for university-level health research of the Kuopio University Hospital 5063598State Research Funding for university-level health research of the Kuopio University Hospital 5063599State Research Funding for university-level health research of the Kuopio University Hospital 56542437Vilho, Yrjö and Kalle Väisälä Foundation
6 · The paper itself

Abstract

Early detection of cartilage degeneration remains a critical unmet clinical need. While contrast-enhanced computed tomography shows promise in detecting early structural and compositional changes in articular cartilage, full adoption into clinical use requires a comprehensive understanding of how contrast agents affect cartilage function, including potential biomechanical alterations. This study investigates how exposure to two contrast agents, pre-clinical ultrasmall cationic tantalum oxide nanoparticles (Ta

Indexed as

Cartilage, ArticularContrast MediaNanoparticlesOxidesTantalumTriiodobenzoic AcidsAnimalsBiomechanical PhenomenaCattleContrast MediaiodixanolOxidesTantalumtantalum oxideTriiodobenzoic Acidsarticular cartilagebiomechanicscontrast agentsfinite element modelingmicrocomputed tomography

Identifiers

PMID42895991
PMCPMC13679883

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.