Evidence map›Paper›PMID 42895730›Full record

ArticleJAMA neurology2026

Vascular Risk Factors and Late-Onset Epilepsy.

Hyunmi Choi, Jose Gutierrez, Tian Wang, Minghua Liu, Cheng-Shiun Leu, Sylwia Misiewicz, Jiying Han, Natalie A Bello, Mary L Biggs, Emily M Briceño and 27 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JAMA neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

Hyunmi ChoiDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York.
Jose GutierrezDepartment of Neurology, University of Miami, Miami, Florida.
Tian WangDepartment of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York.
Minghua LiuDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York.
Cheng-Shiun LeuDepartment of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York.
Sylwia MisiewiczDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York.
Jiying HanDepartment of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York.
Natalie A BelloDepartment of Cardiology, Smidt Heart Center, Cedars Sinai Medical Center, Los Angeles, California.
Mary L BiggsDepartment of Biostatistics, University of Washington, Seattle.
Emily M BriceñoDepartment of Physical Medicine and Rehabilitation, University of Michigan Medical School, Ann Arbor.
Adam M BrickmanTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York.
James F BurkeDepartment of Neurology, The Ohio State University, Columbus.
Ligong ChenDepartment of Epidemiology, University of Alabama at Birmingham.
Lisandro D ColantonioDepartment of Epidemiology, University of Alabama at Birmingham.
Stefany P Diaz AndinoDepartment of Public Health, Brigham Young University, Provo, Utah.
Mitchell S V ElkindDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York.
Annette L FitzpatrickDepartments of Family Medicine and Epidemiology, University of Washington, Seattle.
Christopher Gonzalez CoronaDepartment of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois.
Rebecca F GottesmanDivision of Intramural Research, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland.
Alden L GrossDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Lei HuangDepartment of Epidemiology, University of Alabama at Birmingham.
Emily L JohnsonDepartment of Neurology, Johns Hopkins University, Baltimore, Maryland.
W Craig JohnsonDepartment of Biostatistics, University of Washington, Seattle.
Deborah A LevineDepartment of Internal Medicine, University of Michigan, Ann Arbor.
W T LongstrethDepartment of Neurology, University of Washington, Seattle.
Sofia Pelagalli MaiaDepartment of Public Health, Brigham Young University, Provo, Utah.
Richard P MayeuxDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York.
Brian C PetersenDepartment of Public Health, Brigham Young University, Provo, Utah.
Oluwadamilola ObalanaDepartment of Public Health, Brigham Young University, Provo, Utah.
Dolly Reyes-DumeyerDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York.
Tatjana RundekDepartment of Neurology, University of Miami, Miami, Florida.
Danurys SanchezDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York.
Steven J SheaDepartment of Medicine, Columbia University, New York, New York.
Kevin StrobinoDepartment of Neurology, Cornell University, New York, New York.
Sarah E TomDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York.
Carolyn W ZhuDepartment of Geriatrics and Palliative Medicine, Mount Sinai School of Medicine, New York, New York.
Evan L ThackerDepartment of Public Health, Brigham Young University, Provo, Utah.

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
VASCULAR FACTORS AND MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASEP01AG007232 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI MANLY, JENNIFER JAIE · 1989 to 2008
$21.7M
STROKE INCIDENCE AND RISK FACTORS IN A TRI-ETHNIC REGIONR01NS029993 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ELKIND, MITCHELL S, SACCO, RALPH L. · 1993 to 2019
$19.2M
Task Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - COORDINATING CENTER - TASK AREA B.2 AND B.375N92022D00001 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID · 2022 to 2025
$13.7M
Epidemiological and Genetic Investigations of Blood-Based Biomarkers for Alzheimer's Disease in the Multiethnic, Washington Heights, Inwood, Columbia Aging Project (WHICAP)R01AG072474 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRICKMAN, ADAM M, MANLY, JENNIFER JAIE · 2021 to 2025
$13.3M
Epidemiological Integration of Genetic Variants and Metabolomics Profiles in Washington Heights Columbia Aging ProjectRF1AG066107 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P, MILLER, GARY W · 2020 to 2022
$11.4M
Epidemiology of Biomarkers of Risk and Progression in LOADR01AG037212 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P, SCHUPF, NICOLE · 2010 to 2015
$10.1M
Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5M
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS 75N92021D00006NHLBI NIH HHS 75N92022D00001NHLBI NIH HHS 75N92022D00002NHLBI NIH HHS 75N92022D00003NHLBI NIH HHS 75N92022D00004NHLBI NIH HHS 75N92022D00005NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL172803NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL130114NIA NIH HHS P01 AG007232NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG037212NIA NIH HHS R01 AG072474NIA NIH HHS R01 AG074355NIA NIH HHS RF1 AG054023NIA NIH HHS RF1 AG066107NIEHS NIH HHS 75N98025D00022NIEHS NIH HHS 75N98025D00024NIEHS NIH HHS 75N98025D00025NIEHS NIH HHS 75N98025D00026NIEHS NIH HHS 75N98025D00027NIEHS NIH HHS 75N98025D00028NIH HHS 75N93022D00002NINDS NIH HHS R01 NS029993NINDS NIH HHS U01 NS041588
6 · The paper itself

Abstract

Importance: Late-onset epilepsy (LOE; onset at age ≥65 years) is increasingly recognized in older adults and may be associated with vascular risk. Objective: To identify vascular risk factors (VRFs) associated with incident LOE in older adults. Design, Setting, and Participants: This study is an individual participant data meta-analysis of 6 US population-based prospective cohort studies (the Epilepsy-Cog Study). In 5 cohorts linked to Medicare for epilepsy case ascertainment, follow-up for LOE began when a participant had accrued 2 years of continuous fee-for-service enrollment and was 65 years of age or older and extended to the end of continuous enrollment. Claims linkage covered 1991-2018 in the Atherosclerosis Risk in Communities Study (ARIC), 1992-2019 in the Cardiovascular Health Study (CHS), 2000-2019 in the Multi-Ethnic Study of Atherosclerosis (MESA), 2000-2020 in the Reasons for Geographic and Racial Differences in Stroke Study (REGARDS), and 1999-2019 in the Washington Heights/Inwood Columbia Aging Project (WHICAP). In the Northern Manhattan Study (NOMAS), which was not Medicare linked and used cohort-based epilepsy case ascertainment, follow-up for LOE began at cohort entry in 1993-2008 and extended to 2024. Data analysis was completed in January 2026. Exposures: Sociodemographic characteristics and VRFs assessed by self-report, examinations, laboratory measures, and medication use. Main Outcome and Measures: The primary outcome was incident LOE. Associations between risk factors and incident LOE were evaluated using multivariable Cox proportional hazards models to estimate hazard ratios. Results: From 43 753 participants in Epilepsy-Cog, 551 participants with prevalent epilepsy and 945 with no follow-up after Epilepsy-Cog baseline were excluded. Among 42 257 participants (mean [SD] age, 71.4 [6.9] years; 23 383 [56.0%] female) followed up for a mean (SD) of 9.3 (6.2) years, 1500 participants (3.5%) developed LOE (3.8 per 1000 person-years). In fully adjusted models, LOE risk was higher with current smoking (HR = 1.39; 95% CI, 1.18-1.64), hypertension (HR = 1.17; 95% CI, 1.04-1.31), diabetes (HR = 1.42; 95% CI, 1.25-1.62), chronic kidney disease (HR = 1.29; 95% CI, 1.13-1.48), history of stroke (HR = 1.99; 95% CI, 1.63-2.43), and apolipoprotein E ε4 allele (1 ε4 allele: HR = 1.22; 95% CI, 1.07-1.39; 2 ε4 alleles: HR = 1.84; 95% CI, 1.36-2.50). Associations of VRFs with LOE were similar across age, sex, and race and ethnicity subgroups. Conclusions and Relevance: In this pooled analysis of 6 US cohorts, multiple VRFs and a history of stroke were associated with incident LOE. These findings suggest that LOE may reflect the underlying burden of brain vascular disease.

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PMID42895730
PMCPMC13681222

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