ArticleNatural products and bioprospecting2026
Increase in 6-pentyl-alpha-pyrone production by Trichoderma spp. in liquid medium using in situ removal by adsorbent resin.
Article in Natural products and bioprospecting, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The Trichoderma-produced secondary metabolite 6-pentyl-alpha-pyrone (6-PP) has demonstrated promise for agricultural applications, but cost-effective bioproduction remains limited by product inhibition during fermentation. This study aimed to evaluate the effect of media type on 6-PP production in T. atroviride IMI206040, screen production by nine New Zealand Trichoderma strains, and assess Amberlite XAD-4 in situ product removal in five strains to overcome self-inhibition. T. atroviride IMI206040 was cultured for 5 days in potato dextrose broth (PDB) or minimal media supplemented with ammonium or nitrate, and 6-PP production was assessed by thin-layer chromatography (TLC). The ten Trichoderma strains were cultured for 7 days in PDB and 6-PP production quantified by spectrophotometry. Finally, five strains were cultured in PDB for 14 days with and without Amberlite XAD-4, and 6-PP quantified by spectrophotometry and gas chromatography (GC). In T. atroviride IMI206040, PDB supported the highest 6-PP production, while ammonium-based minimal media repressed production, consistent with nitrogen catabolite repression. Screening revealed up to 14.6-fold variation among strains, with T. gamsii LU771 and T. viridescens LU1369 as the highest producers. Spectrophotometric and GC measurements showed strain-dependent disagreement, indicating GC is more reliable for cross-strain comparisons. Amberlite XAD-4 increased total 6-PP production 3- to 5.2-fold across all five strains, with > 99% of secreted 6-PP sequestered. The highest-producing strains, T. gamsii LU771 and T. atroviride LU132, achieved titres approaching 500 mg/L. These findings support Amberlite XAD-4 as an effective in situ product removal method for increasing 6-PP bioproduction and identifying strains with high intrinsic biosynthetic capacity in the absence of product inhibition.
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