ReviewScience China. Life sciences2026
Epigenetics in development, disease, and therapy: from mechanisms to clinical interventions.
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Review in Science China. Life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
69 authors.
Yixuan Ren *Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Lei Yang *State Key Laboratory of Cardiology and Medical Innovation Center, Department of Reproductive Medicine Center, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Boyi Fei *Center for Stem Cell Biology and Regenerative Medicine, MOE Key Laboratory of Bioinformatics, New Cornerstone Science Laboratory, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
Rong Guo *Department of Basic Research, Guangzhou National Laboratory, Guangzhou, 510005, China.
Junran Huang *State Key Laboratory of Molecular Oncology, School of Basic Medical Sciences, Tsinghua University, Beijing, 100084, China.
Zhenghao Xu *Center for Stem Cell Biology and Regenerative Medicine, MOE Key Laboratory of Bioinformatics, New Cornerstone Science Laboratory, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
Ruoran Wang *College of Life Sciences, Zhejiang University, Hangzhou, 310058, China.
Pinqi Zhang *State Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Dandan Cao *State Key Laboratory of Cardiovascular Diseases and Medical Innovation Center, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Pan Chen *Center for Biomedical Digital Science, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong-Hong Kong Joint Laboratory for Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.
Yingxi Chen *State Key Laboratory of Complex, Severe, and Rare Diseases, Institute of Basic Medical Sciences & School of Basic Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.
Yingzi Cui *MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing, 100871, China.
Qing Gao *State Key Laboratory of Complex, Severe, and Rare Diseases, Institute of Basic Medical Sciences & School of Basic Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.
Bo He *Peking University Chengdu Academy for Advanced Interdisciplinary Biotechnologies, Chengdu, 610095, China.
Jiangping He *Faculty of Life and Health Sciences, Shenzhen University of Advanced Technology, Shenzhen, 518107, China.
Gongcheng Hu *Department of Basic Research, Guangzhou National Laboratory, Guangzhou, 510005, China.
Feng Jin *State Key Laboratory of Metabolism and Regulation in Complex Organisms, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, College of Life Sciences, Wuhan University, Wuhan, 430072, China.
Yanhe Li *Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Dongdong Liu *Gene Editing Center, School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Xin Liu *Institute of Stem Cell and Regenerative Biology, College of Animal Science and Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China.
Xinyi Liu *Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Yanjiang Liu *State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510120, China.
Yunzhi Liu *State Key Laboratory of Experimental Hematology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Medical University Cancer Institute and Hospital, Department of Cell Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Zhuojuan Luo *Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, 210096, China.
Yuxiao Lu *Department of Basic Research, Guangzhou National Laboratory, Guangzhou, 510005, China.
Jie Qi *State Key Laboratory of Cardiovascular Diseases and Medical Innovation Center, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Mingzhu Wang *Frontier Science Center for Stem Cell Research, Tongji University, Shanghai, 200092, China.
Yiyun Wang *State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, 610064, China.
Junfei Wen *State Key Laboratory of RNA Innovation, Science and Engineering, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
Jacqueline Jufen Zhu *State Key Laboratory of Organ Regeneration and Reconstruction, Human Organ Physiopathology Emulation System, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
Chong ChenState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, 610064, China. chongchen@scu.edu.cn.
Jiekai ChenCenter for Biomedical Digital Science, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong-Hong Kong Joint Laboratory for Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China. chen_jiekai@gibh.ac.cn.
Albert Wu ChengState Key Laboratory of Organ Regeneration and Reconstruction, Human Organ Physiopathology Emulation System, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. albert.cheng@ioz.ac.cn.
Junjun DingCenter for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China. dingjunj@mail.sysu.edu.cn.
Peng DuMOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing, 100871, China. pengdu@pku.edu.cn.
Lan-Tao GouState Key Laboratory of RNA Innovation, Science and Engineering, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China. goulantao@sibcb.ac.cn.
Jing-Dong Jackie HanPeking University Chengdu Academy for Advanced Interdisciplinary Biotechnologies, Chengdu, 610095, China. jackie.han@pku.edu.cn.
Haitao LiTsinghua-Peking Center for Life Sciences, Beijing, 100084, China. lht@tsinghua.edu.cn.
Chengqi LinKey Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, 210096, China. cqlin@seu.edu.cn.
Mo-Fang LiuShanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China. mfliu@tongji.edu.cn.
Wenqiang LiuShanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China. liuwenqiang@tongji.edu.cn.
Xiaoyu LiuClinical and Translational Research Center of Shanghai First Maternity & Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China. liuxiaoyu@tongji.edu.cn.
Zhiyong MaoAging Biomarker Consortium (ABC), Beijing, 100101, China. zhiyong_mao@tongji.edu.cn.
Yi-Liang MiaoInstitute of Stem Cell and Regenerative Biology, College of Animal Science and Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China. miaoyl@mail.hzau.edu.cn.
Jing QuState Key Laboratory of Organ Regeneration and Reconstruction, Human Organ Physiopathology Emulation System, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. qujing@ioz.ac.cn.
Wei QiGene Editing Center, School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. qiwei@shanghaitech.edu.cn.
Min WuState Key Laboratory of Metabolism and Regulation in Complex Organisms, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, College of Life Sciences, Wuhan University, Wuhan, 430072, China. wumin@whu.edu.cn.
Xudong WuState Key Laboratory of Experimental Hematology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Medical University Cancer Institute and Hospital, Department of Cell Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China. wuxudong@tmu.edu.cn.
Jiemin WongShanghai Key Laboratory of Regulatory Biology, Fengxian District Central Hospital-ECNU Joint Center of Translational Medicine, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China. jmweng@bio.ecnu.edu.cn.
Chengqi YiBeijing Advanced Center of RNA Biology, Peking University, Beijing, 100871, China. chengqi.yi@pku.edu.cn.
Rui YueState Key Laboratory of Cardiovascular Diseases and Medical Innovation Center, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China. ryue@tongji.edu.cn.
Na ZhangSchool of Life Sciences, Jilin University, Changchun, 130012, China. zhangna@jlu.edu.cn.
Weiqi ZhangAging Biomarker Consortium (ABC), Beijing, 100101, China. zhangwq@big.ac.cn.
Yong ZhangState Key Laboratory of Complex, Severe, and Rare Diseases, Institute of Basic Medical Sciences & School of Basic Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China. yongzhang@ibms.pumc.edu.cn.
Shuai ZhaoState Key Laboratory of Molecular Oncology, Beijing Frontier Research Center for Biological Structure, School of Basic Medical Sciences, Tsinghua University, Beijing, 100084, China. shuai@tsinghua.edu.cn.
Dahai ZhuState Key Laboratory of Complex, Severe, and Rare Diseases, Institute of Basic Medical Sciences & School of Basic Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China. dhzhu@pumc.edu.cn.
Hongjie YaoDepartment of Basic Research, Guangzhou National Laboratory, Guangzhou, 510005, China. yao_hongjie@gzlab.ac.cn.
Hai-Ning DuCollege of Life Sciences, Frontier Science Center for Immunology and Metabolism, Hubei Key Laboratory of Cell Homeostasis, TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan, 430072, China. hainingdu@whu.edu.cn.
Haiyan LinState Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Research Center for Basic Biological Sciences, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, 430072, China. linhaiyan@whu.edu.cn.
Zeming WuAging Biomarker Consortium (ABC), Beijing, 100101, China. wuzeming@jlu.edu.cn.
Qianhua XuCenter for Stem Cell Biology and Regenerative Medicine, MOE Key Laboratory of Bioinformatics, New Cornerstone Science Laboratory, School of Life Sciences, Tsinghua University, Beijing, 100084, China. xuqianhua@mail.tsinghua.edu.cn.
Yawei GaoState Key Laboratory of Cardiology and Medical Innovation Center, Department of Reproductive Medicine Center, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China. gaoyawei@tongji.edu.cn.
Mo ChenState Key Laboratory of Molecular Oncology, School of Basic Medical Sciences, Tsinghua University, Beijing, 100084, China. mochen@mail.tsinghua.edu.cn.
Guohong LiNew Cornerstone Science Laboratory. State Key Laboratory of Metabolism and Regulation in Complex Organisms, Frontier Science Center for Immunology and Metabolism, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, 430072, China. liguohong@whu.edu.cn.
Guang-Hui LiuState Key Laboratory of Organ Regeneration and Reconstruction, Human Organ Physiopathology Emulation System, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. ghliu@ioz.ac.cn.
Zhuo-Xian MengDepartment of Pathology and Pathophysiology and Department of Cardiology of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China. zxmeng@zju.edu.cn.
Wei XieCenter for Stem Cell Biology and Regenerative Medicine, MOE Key Laboratory of Bioinformatics, New Cornerstone Science Laboratory, School of Life Sciences, Tsinghua University, Beijing, 100084, China. xiewei121@tsinghua.edu.cn.
Bing ZhuState Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. zhubing@ibp.ac.cn.
Shaorong GaoShanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China. gaoshaorong@tongji.edu.cn.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epigenetics, defined as the regulatory mechanisms that modulate genetic information flow without altering the DNA sequence, plays a crucial role in development, aging, and disease. This review explores the key epigenetic mechanisms-DNA methylation, histone modifications, chromatin remodeling, and non-coding RNAs-and their contributions to cellular differentiation, tissue homeostasis, and disease progression. We focus on their roles in gametogenesis, early development, stem cell reprogramming, and aging, highlighting how epigenetic alterations influence health and disease. The review also discusses emerging therapeutic approaches targeting epigenetic modifications, with potential applications in disease treatment and longevity. Finally, we examine the future of epigenetic research, emphasizing the need for precision therapies and the integration of epigenetic tools in clinical practice.
Indexed as
cancerepigeneticsepigenetic therapymammalian developmentsenescence
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PMID
42895683What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.