Evidence map›Paper›PMID 42895614›Full record

ArticleJournal of fluorescence2026

Enhanced Fluorescence and Fenton-reaction in Peroxidase Nanozyme of Functionalized Fe, N, S-Carbon Dots: H₂O₂-Induced Surface Oxidation and Detection using Conventional Turn-off and Smartphone-based Colorimetric Methods.

Shaimaa Abubakr Abdalla, Shilan A Fatah, Sameera Sh Mohammed Ameen, Khalid M Omer

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Article in Journal of fluorescence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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4 authors.

Shaimaa Abubakr AbdallaDepartment of Chemistry, College of Science, University of Charmo, Chamchamal, Kurdistan Region, 46023, Iraq.
Shilan A FatahDepartment of Pharmacy, Kurdistan Technical Institute, Sulaimani, KGR, 46001, Iraq.
Sameera Sh Mohammed AmeenDepartment of Chemistry, College of Science, University of Zakho, Zakho, Kurdistan Region, 42002, Iraq.
Khalid M OmerDepartment of Chemistry, College of Science, University of Sulaimani, Sulaymaniyah, Kurdistan Region, 46002, Iraq. khalid.omer@univsul.edu.iq.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peroxidase nanozymes and fluorophores have attracted considerable attention in catalysis and luminescence-based sensing applications. In this study, novel class of iron-, nitrogen-, and sulfur-functionalized carbon dots (Fe/N/S-CDs) featuring with inherent fluorescence and peroxidase-like activity were developed successfully via a facile hydrothermal approach. The Fe/N/S-CDs displayed strong blue fluorescence under UV irradiation with a high quantum yield of 44.5%. The incorporation of Fe active centers within the carbon framework and surface structure endowed Fe/N/S-CDs with efficient peroxidase-like activity toward hydrogen peroxide (H₂O₂) through a Fenton-like reaction, producing hydroxyl radicals (•OH). The generated •OH radicals induced surface oxidation of Fe/N/S-CDs, resulting in fluorescence quenching and enabling a selective "on-off" sensing mechanism. Structural and spectroscopic analyses confirmed H₂O₂-induced surface oxidation of Fe/N/S-CDs, accompanied by increased oxygen-containing functional groups, altered electronic structure, and sustained Fe²⁺/Fe³⁺ redox cycling. Based on this strategy, a dual-mode sensing platform integrating fluorometric detection and smartphone-assisted colorimetric analysis was developed for H₂O₂ monitoring. The proposed sensor achieved low detection limits of 3.55 µM and 8.99 µM for fluorometric and smartphone-based colorimetric detection, respectively. Wide linear ranges of 4-5000 µM for fluorometric analysis and 30-1000 µM for smartphone-based detection were obtained. The practical applicability of the sensing platform was evaluated using commercial and medical H₂O₂ samples, demonstrating excellent recovery values ranging from 98.9% to 104.8% with low RSDs. The integration of functionalized Fe/N/S-CD nanozymes with smartphone-based analysis establishes a robust dual-mode sensing platform that paves the way for accessible, reliable, and real-time chemical sensing in environmental, biomedical, and food safety applications.

Indexed as

Fenton-like reactionFluorescence quenchingFunctionalized carbon dotsHydrogen peroxidePeroxidase-like nanozymeSmartphone-assisted visual detection

Identifiers

PMID42895614

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