Evidence map›Paper›PMID 42895605›Full record

ArticleInfection2026

An impaired T-cell-mediated mitogen response as a potential biomarker to aid in clinical diagnosis of pulmonary tuberculosis.

Difery Minadzi, Augustine Yeboah, Millicent Lamptey, Monika M Vivekanandan, Joseph F Arthur, Hubert S Ahor, Wilfred Aniagyei, Samuel A Sakyi, Anthony A A Awuah, Rejoice A Arthur and 15 more

Abstract read
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In one paragraph

Article in Infection, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Difery MinadziKumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Kumasi, Ghana.
Augustine YeboahKumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Kumasi, Ghana.
Millicent LampteyKumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Kumasi, Ghana.
Monika M VivekanandanDepartment of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital Duesseldorf, Heinrich-Heine University, 40225, Duesseldorf, Germany.
Joseph F ArthurDepartment of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital Duesseldorf, Heinrich-Heine University, 40225, Duesseldorf, Germany.
Hubert S AhorDepartment of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital Duesseldorf, Heinrich-Heine University, 40225, Duesseldorf, Germany.
Wilfred AniagyeiDepartment of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital Duesseldorf, Heinrich-Heine University, 40225, Duesseldorf, Germany.
Samuel A SakyiDepartment of Molecular Medicine, School of Medical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.
Anthony A A AwuahDepartment of Molecular Medicine, School of Medical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.
Rejoice A ArthurKumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Kumasi, Ghana.
Victoria A OforiKumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Kumasi, Ghana.
Albert D KegyaKumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Kumasi, Ghana.
Linda A AmoakoaKumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Kumasi, Ghana.
Ernest AdankwahKumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Kumasi, Ghana.
Dorcas O OwusuKumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Kumasi, Ghana.
Ijeoma C Anyitey-KokorDepartment of Medical Imaging, KNUST, Kumasi, Ghana.
Mohammed K AbassAgogo Presbyterian Hospital, Agogo, Ghana.
Fredrick G AprakuKumasi South Government Hospital, Atonsu, Kumasi, Ghana.
Nana K Ayisi-BoatengUniversity Hospital, KNUST, Kumasi, Ghana.
Seth AdaneAtebubu-Amantin Municipal Hospital, Atebubu, Ghana.
Salisu ZakariaSene West Health Directorate, Kwame Danso, Ghana.
Ertan MayatepekDepartment of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital Duesseldorf, Heinrich-Heine University, 40225, Duesseldorf, Germany.
Julia SeyfarthDepartment of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital Duesseldorf, Heinrich-Heine University, 40225, Duesseldorf, Germany.
Richard O PhillipsKumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Kumasi, Ghana.
Marc JacobsenDepartment of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital Duesseldorf, Heinrich-Heine University, 40225, Duesseldorf, Germany. marc.jacobsen@med.uni-duesseldorf.de.ORCID http://orcid.org/0000-0002-4703-5652

Funding

Deutsche Forschungsgemeinschaft JA 1479/14-1Jürgen Manchot Stiftung MOI-5 graduate school
6 · The paper itself

Abstract

purposeA considerable proportion of suspected pulmonary tuberculosis (pTB) cases are identified and treated on the basis of clinical diagnoses, as it is often not possible to confirm Mycobacterium tuberculosis (Mtb) infection. In the absence of pathogen detection, supplementary indicators, such as immunological biomarkers, would facilitate TB diagnostic decision-making.

methodsIn this prospective case-control study conducted in Ghana, patients with suspected pTB (n = 83) were divided into three subgroups: confirmed cases with high (pTB

resultsAbout half of the pTB patients were pTB

conclusionThis study underscores the importance of clinical pTB diagnosis and identifies a reduced T-cell cytokine response to phytohemagglutinin as a potential biomarker.

Indexed as

Clinical diagnosisImmunopathologyPHAPulmonary tuberculosis (pTB)

Identifiers

PMID42895605

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.