SynthesisEuropean journal of pediatrics2026
Paediatric Helicobacter pylori infection and allergic and inflammatory diseases: a contemporary systematic review with meta-analysis.
Synthesis in European journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helicobacter pylori (H. pylori) infection is prevalent worldwide, and its potential protective role in allergic and immune diseases has been a topic of speculation. This systematic review aims to analyse recent literature to establish a consensus on this relationship. Articles published in the past 12 years regarding association of H. pylori and various allergic diseases were screened. Thirty-five articles from three databases were assessed for bias using the ROBINS-E tool. Objective data from each article were collected for this review. Among the reviewed articles, 14 focused on asthma, 10 on eliac disease(CeD), 5 on eosinophilic esophagitis (EoE), 7 on inflammatory bowel disease (IBD), and 8 on mixed conditions. In the asthma meta-analysis, H. pylori infection was not significantly associated with asthma overall (OR 0.75, 95% CI 0.54-1.05; I
conclusionCurrent paediatric evidence does not demonstrate a significant overall association between H. pylori infection and asthma. Apparent inverse associations were confined to specific diagnostic and risk-of-bias subgroups. Evidence for celiac disease, IBD, EoE, and other immune-mediated disorders remains inconsistent. More prospective paediatric studies are needed to understand the immune modulation of H. pylori infection. WHAT IS KNOWN: • The relationship between Helicobacter pylori infection and allergic or immune-mediated diseases remains complex and incompletely understood. • Previous studies, including mixed studies with adult and paediatric populations, have reported inconsistent and sometimes conflicting associations. WHAT IS NEW: • This is the first comprehensive paediatric review covering multiple conditions simultaneously, synthesising evidence on the association between Helicobacter pylori infection and allergic and immune-mediated diseases. • Analysis of paediatric data found no overall association between H. pylori infection and asthma risk. Histology-based studies confirmed this finding, whereas a slight inverse association was observed only in studies using non-invasive diagnostic methods (UBT or SAT) and in those with a higher risk of bias.
Indexed as
Identifiers
42895565What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.