In one paragraphArticle in The Journal of experimental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
41 authors.
Masayuki Nishide *Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan.ORCID 0000-0001-6060-1228 Hiroaki Matsushita *Department of Advanced Clinical and Translational Immunology, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan.ORCID 0009-0008-3528-4150 Yumiko Mizuno *Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan.ORCID 0009-0001-0893-2502 Kei Nishimura *Department of Advanced Clinical and Translational Immunology, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan.ORCID 0000-0002-7293-2160 Patrick M LelliottBiophotonics Laboratory, World Premier International Research Center Initiative (WPI), Immunology Frontier Research Center (IFReC), The University of Osaka, Suita, Osaka, Japan.ORCID 0000-0002-4666-1846 Shoji KawadaDepartment of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan.ORCID 0009-0007-5781-9550 Daisuke MotookaNGS Core Facility, Bioinformatics Center, Research Institute for Microbial Diseases, The University of Osaka, Suita, Osaka, Japan.ORCID 0000-0002-4616-9608 Shoichi MetsugiDepartment of Advanced Clinical and Translational Immunology, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan.ORCID 0009-0007-6399-5729 Hiroshi ShimagamiDepartment of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan.ORCID 0000-0001-7820-364X Atsuko Tsujii MiyamotoDepartment of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan.ORCID 0009-0007-3216-4949 Yasuhiro KatoDepartment of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan.ORCID 0000-0002-4050-2350 Kohei TsujimotoDepartment of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan.ORCID 0000-0001-6958-2983 Ryuya EdahiroDepartment of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan.ORCID 0000-0001-5009-6408 Yuya ShiraiDepartment of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan.ORCID 0000-0002-0518-9020 Yuji YamamotoDepartment of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan.ORCID 0000-0002-5489-5079 Yujiro NaitoDepartment of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan.ORCID 0000-0003-0633-4936 Hachiro KonakaDepartment of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan.ORCID 0009-0008-9923-5024 Mayuko IzumiDepartment of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan.ORCID 0000-0002-1575-3748 Maiko NaitoDepartment of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan.ORCID 0000-0002-4360-7043 Yoshimitsu NakanishiDepartment of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan.ORCID 0000-0001-6172-6364 Tomoko Namba-HamanoDepartment of Nephrology, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan.ORCID 0000-0002-6049-7616 Kazunori InoueDepartment of Nephrology, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan.ORCID 0000-0002-7149-6651 Atsushi TakahashiDepartment of Nephrology, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan.ORCID 0009-0002-9653-6303 Masayuki MizuiDepartment of Nephrology, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan.ORCID 0000-0003-2543-8108 Shigeaki NakazawaDepartment of Urology, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan.ORCID 0000-0001-5857-3483 Yoichi KakutaDepartment of Urology, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan.ORCID 0000-0001-5339-4312 Nicolas I SmithBiophotonics Laboratory, World Premier International Research Center Initiative (WPI), Immunology Frontier Research Center (IFReC), The University of Osaka, Suita, Osaka, Japan.ORCID 0000-0002-7835-199X Yoshitaka IsakaDepartment of Nephrology, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan.ORCID 0000-0002-0820-7167 Norio NonomuraDepartment of Urology, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan.ORCID 0000-0002-6522-6233 Yukinori OkadaDepartment of Statistical Genetics, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan.ORCID 0000-0002-0311-8472 Masashi NarazakiDepartment of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan.ORCID 0000-0002-5613-4409 Atsushi KumanogohDepartment of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan.ORCID 0000-0003-4749-7117 Funding
Japan Agency for Medical Research and Development 223fa627001Japan Agency for Medical Research and Development 223fa627002Japan Agency for Medical Research and Development 223fa627010Japan Agency for Medical Research and Development 223fa627011Japan Agency for Medical Research and Development 22gm1810003Japan Agency for Medical Research and Development 22zf0127008Japan Agency for Medical Research and Development 24ek0109594Japan Agency for Medical Research and Development 24ek0410113Japan Agency for Medical Research and Development 24ek0410124Japan Agency for Medical Research and Development 24gm1810011Japan Agency for Medical Research and Development 24kk0305022Japan Agency for Medical Research and Development 24km0405217Japan Agency for Medical Research and Development 24tm0524002Japan Agency for Medical Research and Development 24wm0625504Japan Agency for Medical Research and Development 25gm7110005Japan Science and Technology Agency JPMJFR235BJapan Science and Technology Agency JPMJMS2021Japan Science and Technology Agency JPMJMS2024Japan Society for the Promotion of Science JP18H05282Japan Society for the Promotion of Science JP24K10597Japan Society for the Promotion of Science JP24K11596Japan Society for the Promotion of Science JP25H01057Ono Pharmaceutical FoundationRIKENTakeda Science FoundationUniversity of Osaka
6 · The paper itselfAbstract
Autoantibody-mediated inflammation drives tissue injury in autoimmune diseases, yet how pathogenic antibodies evoke local immune activation remains poorly understood. Here, we show that spatially organized neutrophil-epithelial niches contribute to kidney injury in myeloperoxidase (MPO)-antineutrophil cytoplasmic antibody-associated glomerulonephritis. Single-cell-resolved spatial transcriptomics of treatment-naïve patient kidney biopsies identified early-phase inflammatory niches enriched with HAVCR1+ injured proximal tubular epithelial cells, neutrophils, lymphocytes, and TREM2+ macrophages. Injured epithelial cells expressed chemokines including CXCL6 and CXCL16, defining a microenvironment associated with local immune cell accumulation. Neutrophils within these niches were characterized by transcriptional programs enriched for type II interferon and Fcγ receptor (FcγR)-related signaling. Mechanistically, combinations of monoclonal anti-MPO antibodies recognizing distinct epitopes enhanced neutrophil activation and induced pauci-immune crescentic glomerulonephritis in mice, recapitulating key aspects of epithelial injury observed in human kidneys. One-armed anti-MPO antibodies engineered to minimize FcγR engagement ameliorated kidney injury in mice. Together, these findings identify pathogenic neutrophil-epithelial niche formation as a driver of autoimmune kidney injury.
Indexed as
Antibodies, Antineutrophil CytoplasmicAutoantibodiesEpithelial CellsEpitopesGlomerulonephritisNeutrophilsAnimalsHumansKidneyMaleMiceMice, Inbred C57BLPeroxidaseReceptors, IgGAntibodies, Antineutrophil CytoplasmicAutoantibodiesEpitopesPeroxidaseReceptors, IgG
Identifiers
PMID42895484
PMCPMC13679361
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