ArticleJournal of global health2026
Impact of prenatal pyrethroid pesticide exposure on neonatal lymphocyte subsets and apoptosis: a birth cohort study.
Article in Journal of global health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Prenatal pyrethroid pesticides (PYRs) exposure may elevate infection diseases susceptibility of children. However, it is unclear the relationship of PYRs exposure and neonatal immune function. We explored the association of PYRs exposure during three trimesters with neonatal immunity and the roles of lymphocyte apoptosis. Methods: Maternal urinary PYRs metabolites (3PBA, 4F3PBA, cis-DBCA) were measured in each trimester. Cord blood lymphocyte subsets and lymphocyte apoptosis rates were assessed by flow cytometry. Multivariate linear regression models were used to examine the associations of trimester-specific and repeated PYRs exposure during pregnancy with neonatal immune function. Results: High-level cis-DBCA exposure (>75th percentile, 0.78 μg/g) in the third trimester was negatively associated with cord blood CD3 Conclusions: High-level maternal PYRs exposure during pregnancy may reduce neonatal lymphocyte counts and increase lymphocyte apoptosis. These effects persist throughout gestation, with the third trimester may represent a sensitive window for adverse effects on immune development.
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