Evidence map›Paper›PMID 42895214›Full record

ArticleTransboundary and emerging diseases2026

Evolutionary Dynamics and Transboundary Spread of Senecavirus A: The Role of Recombination and Global Swine Trade.

Yeqiu Li, Yongqiu Cui, Xinyu Gao, Ying Ji, Penghui Zeng, Siting Li, Junnan Chen, Peng Hui, Jianwei Zhou, Dedong Wang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transboundary and emerging diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yeqiu LiCollege of Veterinary Medicine, Yangzhou University, Yangzhou, China, yzu.edu.cn.
Yongqiu CuiCollege of Veterinary Medicine, Yangzhou University, Yangzhou, China, yzu.edu.cn.
Xinyu GaoCollege of Veterinary Medicine, Yangzhou University, Yangzhou, China, yzu.edu.cn.
Ying JiCollege of Veterinary Medicine, Yangzhou University, Yangzhou, China, yzu.edu.cn.
Penghui ZengCollege of Veterinary Medicine, Yangzhou University, Yangzhou, China, yzu.edu.cn.
Siting LiCollege of Veterinary Medicine, Yangzhou University, Yangzhou, China, yzu.edu.cn.
Junnan ChenCollege of Veterinary Medicine, Yangzhou University, Yangzhou, China, yzu.edu.cn.
Peng HuiCollege of Veterinary Medicine, Yangzhou University, Yangzhou, China, yzu.edu.cn.
Jianwei ZhouCollege of Veterinary Medicine, Yangzhou University, Yangzhou, China, yzu.edu.cn.ORCID https://orcid.org/0009-0001-6703-9466
Dedong WangCollege of Veterinary Medicine, Yangzhou University, Yangzhou, China, yzu.edu.cn.
Jiawu WanCollege of Veterinary Medicine, Yangzhou University, Yangzhou, China, yzu.edu.cn.
Fanshu MaCollege of Veterinary Medicine, Yangzhou University, Yangzhou, China, yzu.edu.cn.ORCID https://orcid.org/0000-0002-5258-9158
Lei HouCollege of Veterinary Medicine, Yangzhou University, Yangzhou, China, yzu.edu.cn.
Jue LiuCollege of Veterinary Medicine, Yangzhou University, Yangzhou, China, yzu.edu.cn.ORCID https://orcid.org/0009-0006-5951-4681

Funding

111 Project D18007Introduction Program of High-Level Innovation and Entrepreneurship Talents in Jiangsu ProvinceNational Natural Science Foundation of China 32372975National Natural Science Foundation of China 32430105Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
6 · The paper itself

Abstract

Senecavirus A (SVA) is an emerging swine pathogen associated with vesicular disease and neonatal mortality, posing significant challenges to global swine health. Here, we report the isolation and identification of two contemporary SVA strains, JS01 and JS02, from clinically suspected cases in China. Both isolates demonstrated high replication competence and clustered within Clade Ib, the dominant globally circulating swine-associated lineage, showing close genetic ties to strains from southeastern China. Phylogenetic and recombination analyses identified multiple putative recombination events within nonstructural genomic regions, suggesting that recombination drives SVA diversification. Spatiotemporal analysis revealed uneven sequence availability over time and across regions, with sampling concentrated in Asia and the Americas during 2015-2018. Phylogeographic reconstruction indicated supported geographic transition connecting Brazil to China, the United States, and Canada. Notably, the inferred dispersal pattern visually overlapped with global live-swine trade networks, pointing to a potential possible link with animal trade. Furthermore, our analysis uncovered a divergent, marine-associated lineage (Clade II) comprising Senecavirus-like sequences from dolphins, which represents a distinct sister clade to terrestrial swine-associated viruses. These findings highlight the evolutionary complexity of SVA and emphasize the importance of genomic surveillance for investigating viral dispersal and its relationship with animal movements.

Indexed as

PicornaviridaePicornaviridae InfectionsSwine DiseasesAnimalsChinaPhylogenyPhylogeographyRecombination, GeneticSwinegenomic characterizationisolation and identificationphylogeographyrecombinantSenecavirus A (SVA)

Identifiers

PMID42895214
PMCPMC13678848

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.