ArticleGut microbes2026
Acute liver injury is triggered by dysbiosis and microbial translocation involving gut-liver axis.
Urmi Halder, Hamida Hamida, Khadija Kakar, Xiaoming Yang, Yin Zhong, Mitzi Nagarkatti, Prakash Nagarkatti
Abstract read
In one paragraphArticle in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
7 authors.
Urmi HalderDepartment of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA.
Hamida HamidaDepartment of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA.
Khadija KakarDepartment of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA.
Xiaoming YangDepartment of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA.
Yin ZhongDepartment of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA.
Mitzi NagarkattiDepartment of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA.
Prakash NagarkattiDepartment of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA.ORCID 0000-0003-2663-0759 Funding
Flow Cytometry and Cell Analysis CoreP30GM154631 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI Mitzi Nagarkatti, Prakash S Nagarkatti · 2024 to 2026
$4.5MRole of the environmental sensor, AhR on colitisR01AI160896 · NIAID · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI NAGARKATTI, MITZI, NAGARKATTI, PRAKASH S · 2021 to 2025
$2.6MEpigenetic mechanisms in Transgenerational Effects of an Environmental PollutantR01ES030144 · NIEHS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI NAGARKATTI, MITZI, NAGARKATTI, PRAKASH S · 2019 to 2023
$2.5MEpigenetic Mechanisms of T Cell Dysregulation in PTSDR01AI129788 · NIAID · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI NAGARKATTI, MITZI · 2017 to 2021
$2.4MAhR ligands in epigenetic dysregulation of T cellsR01AI123947 · NIAID · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI NAGARKATTI, MITZI, NAGARKATTI, PRAKASH S · 2017 to 2021
$1.8MNIAID NIH HHS R01 AI123947NIAID NIH HHS R01 AI129788NIAID NIH HHS R01 AI160896NIEHS NIH HHS R01 ES030144NIGMS NIH HHS P30 GM154631
6 · The paper itselfAbstract
Acute liver injury (ALI) is a severe clinical condition that can progress to chronic liver failure, cirrhosis, or hepatocellular carcinoma, yet therapeutic options remain limited. Here, we investigated how hepatotoxin-induced gut-liver dysbiosis drives hepatic inflammation through microbial crosstalk. Using three murine ALI models, we assessed liver injury, intestinal barrier integrity, microbial composition along the gut-liver axis, and immune activation. Each hepatotoxin recapitulated distinct features of human ALI and induced unique patterns of hepatic and intestinal injury, enabling the progressive translocation of live bacteria from the gut to the liver and bloodstream. ALI was consistently associated with depletion of commensal taxa (
Indexed as
Bacterial TranslocationChemical and Drug Induced Liver InjuryDysbiosisGastrointestinal MicrobiomeLiverAnimalsBacteriaDisease Models, AnimalHumansIntestinal Barrier FunctionMaleMiceMice, Inbred C57BLBacteriomehepatotoxinsinflammatory responsemicrobiota translocationsystemic circulationvirome
Identifiers
PMID42895196
PMCPMC13682391
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