Evidence map›Paper›PMID 42895112›Full record

ArticleDalton transactions (Cambridge, England : 2003)2026

Comparative study of the direct and photocatalytic light activation of platinum(IV) prodrugs.

Kinjal Mileche, Susana M Meza Huaman, Ke Wu, Jake A Vickery, Hannah Coxhead, Alexander N Smith-Xu, Patricia Juhl Allworthy, Jovana Katrinka-Mavrak, Aminesena Baser, Safacan Kolemen and 6 more

Abstract read
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In one paragraph

Article in Dalton transactions (Cambridge, England : 2003), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Kinjal MilecheDepartment of Chemistry, King's College London, 7 Trinity Street, London, SE1 1DB, UK. adam.sedgwick@kcl.ac.uk.
Susana M Meza HuamanDepartment of Chemistry, King's College London, 7 Trinity Street, London, SE1 1DB, UK. adam.sedgwick@kcl.ac.uk.
Ke WuDepartment of Chemistry, King's College London, 7 Trinity Street, London, SE1 1DB, UK. adam.sedgwick@kcl.ac.uk.
Jake A VickeryDepartment of Chemistry, King's College London, 7 Trinity Street, London, SE1 1DB, UK. adam.sedgwick@kcl.ac.uk.ORCID http://orcid.org/0009-0000-8589-6472
Hannah CoxheadDepartment of Chemistry, King's College London, 7 Trinity Street, London, SE1 1DB, UK. adam.sedgwick@kcl.ac.uk.
Alexander N Smith-XuDepartment of Chemistry, King's College London, 7 Trinity Street, London, SE1 1DB, UK. adam.sedgwick@kcl.ac.uk.
Patricia Juhl AllworthyDepartment of Chemistry, King's College London, 7 Trinity Street, London, SE1 1DB, UK. adam.sedgwick@kcl.ac.uk.
Jovana Katrinka-MavrakInstitute of Biomedical Engineering, Department of Engineering Sciences, Old Road Campus Research Building, University of Oxford, Headington, Oxford, UK.
Aminesena BaserGraduate School of Health Sciences, Cellular and Molecular Medicine Program, Koç University, Istanbul, 34450, Turkey.ORCID http://orcid.org/0000-0001-8018-357X
Safacan KolemenDepartment of Chemistry, Koç University, Istanbul 34450, Türkiye.ORCID http://orcid.org/0000-0003-4162-5587
Manuel M MüllerDepartment of Chemistry, King's College London, 7 Trinity Street, London, SE1 1DB, UK. adam.sedgwick@kcl.ac.uk.ORCID http://orcid.org/0000-0001-6701-0893
Mahvash TavassoliCentre for Host-Microbiome Interactions, King's College London, SE1 1UL, London, UK.
Ismael Diez-PerezDepartment of Chemistry, King's College London, 7 Trinity Street, London, SE1 1DB, UK. adam.sedgwick@kcl.ac.uk.ORCID http://orcid.org/0000-0003-0513-8888
Eleanor StrideInstitute of Biomedical Engineering, Department of Engineering Sciences, Old Road Campus Research Building, University of Oxford, Headington, Oxford, UK.ORCID http://orcid.org/0000-0003-3371-5929
John F CallanBiomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland, UK. j.callan@ulster.ac.uk.ORCID http://orcid.org/0000-0002-9286-1312
Adam C SedgwickDepartment of Chemistry, King's College London, 7 Trinity Street, London, SE1 1DB, UK. adam.sedgwick@kcl.ac.uk.ORCID http://orcid.org/0000-0002-3132-2913

Funding

Wellcome Trust
6 · The paper itself

Abstract

Here, we present a comparative study of direct and photocatalyst-mediated photoactivation of reporter-functionalised Pt(IV) prodrugs, Carbo-4NP and CarboNap. Direct blue-light irradiation and green-light activation using the photocatalyst Rose Bengal both achieved rapid and complete Pt(IV) reduction in solution, monitored by UV-Vis and fluorescence spectroscopy. Translation to live cells revealed a marked divergence between the two approaches. Direct blue light (415 nm) photoactivation produced >300-fold enhancement in fluorescence intensities upon probe activation and >10-fold in cytotoxicity. Photocatalytic activation was considerably less effective in cells despite its excellent solution-phase performance. These findings identify direct photoactivation as the superior strategy for intracellular activation of Pt(IV) prodrugs and support the further development of direct light-activated platinum therapeutics.

Identifiers

PMID42895112
PMCPMC13678618

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.