Evidence map›Paper›PMID 42895009›Full record

ArticleJournal of oral & facial pain and headache2026

Association between malocclusion and temporomandibular joint disorders: evidence from a Mendelian randomization study.

Zhouqiang Wu, Sen Wang, Chang Liu, Zhiyi Zhao, Yan Feng, Yue Shan, Wen Li, Mengjie Wu

Abstract read
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In one paragraph

Article in Journal of oral & facial pain and headache, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Zhouqiang Wu *Department of Orthodontics, Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine & Clinical Research Center for Oral Diseases of Zhejiang Province & Key Laboratory of Oral Biomedical Research of Zhejiang Province & Cancer Center of Zhejiang University, 310006 Hangzhou, Zhejiang, China.
Sen Wang *Department of Orthodontics, Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine & Clinical Research Center for Oral Diseases of Zhejiang Province & Key Laboratory of Oral Biomedical Research of Zhejiang Province & Cancer Center of Zhejiang University, 310006 Hangzhou, Zhejiang, China.
Chang LiuDepartment of Orthodontics, Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine & Clinical Research Center for Oral Diseases of Zhejiang Province & Key Laboratory of Oral Biomedical Research of Zhejiang Province & Cancer Center of Zhejiang University, 310006 Hangzhou, Zhejiang, China.
Zhiyi ZhaoDepartment of Orthodontics, Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine & Clinical Research Center for Oral Diseases of Zhejiang Province & Key Laboratory of Oral Biomedical Research of Zhejiang Province & Cancer Center of Zhejiang University, 310006 Hangzhou, Zhejiang, China.
Yan FengDepartment of Orthodontics, Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine & Clinical Research Center for Oral Diseases of Zhejiang Province & Key Laboratory of Oral Biomedical Research of Zhejiang Province & Cancer Center of Zhejiang University, 310006 Hangzhou, Zhejiang, China.
Yue ShanDepartment of Orthodontics, Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine & Clinical Research Center for Oral Diseases of Zhejiang Province & Key Laboratory of Oral Biomedical Research of Zhejiang Province & Cancer Center of Zhejiang University, 310006 Hangzhou, Zhejiang, China.
Wen LiDepartment of Orthodontics, Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine & Clinical Research Center for Oral Diseases of Zhejiang Province & Key Laboratory of Oral Biomedical Research of Zhejiang Province & Cancer Center of Zhejiang University, 310006 Hangzhou, Zhejiang, China.
Mengjie WuDepartment of Orthodontics, Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine & Clinical Research Center for Oral Diseases of Zhejiang Province & Key Laboratory of Oral Biomedical Research of Zhejiang Province & Cancer Center of Zhejiang University, 310006 Hangzhou, Zhejiang, China.

Funding

National Natural Science Foundation of China 82270995
6 · The paper itself

Abstract

backgroundAlthough malocclusion and temporomandibular joint disorders (TMD) frequently co-occur in clinical practice, controversy persists regarding whether this overlap reflects a pathophysiological causal relationship or incidental concurrence. This study aimed to investigate the potential association between malocclusion and TMD using a bidirectional two-sample Mendelian randomization (MR) approach.

methodsBidirectional two-sample MR was performed to evaluate the potential causal relationship between malocclusion and TMD. Summary statistics for malocclusion were obtained from the FinnGen consortium, while TMD datasets were obtained from the FinnGen consortium and an independent genome-wide association study (GWAS) of the UK Biobank (UKB). To account for multiple comparisons, a Bonferroni-corrected significance threshold of 0.00625 was applied. The strength of the instrumental variables (IVs) was assessed using

resultsConvergent evidence from IVW, WM, and penalized weighted median estimators suggested potential causal effects of distal bite, deep bite, and open bite on TMD susceptibility. After Bonferroni correction, deep bite remained significantly associated with TMD. The mean

conclusionsThis MR study provides evidence that several malocclusion types, including distal bite, deep bite, and open bite, are potentially causally associated with TMD, with deep bite showing the strongest association.

Indexed as

MalocclusionMendelian Randomization AnalysisTemporomandibular Joint DisordersGenome-Wide Association StudyHumansMalocclusionMendelian randomizationTemporomandibular joint disorders

Identifiers

PMID42895009
PMCPMC13678557

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