Evidence map›Paper›PMID 42895003›Full record

ReviewJournal of oral & facial pain and headache2026

Beyond the jaw: vocal, oropharyngeal and cognitive-linguistic biomarkers for precision pain phenotyping in TMD.

Candice J Adams-Mitchell, Jacob Koshy, Rory Reever, Amir Shaikh, Patricia Lopes Cabrera, Selenia Rubio, Margarete C Ribeiro-Dasilva, Roger B Fillingim

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of oral & facial pain and headache, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Candice J Adams-MitchellDepartment of Speech, Language and Hearing Sciences, College of Public Health and Health Professions, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0002-3585-364X
Jacob KoshyPain Research and Intervention Center (PRICE), University of Florida, Gainesville, FL 32611, USA.ORCID 0009-0007-0317-6238
Rory ReeverPain Research and Intervention Center (PRICE), University of Florida, Gainesville, FL 32611, USA.ORCID 0009-0007-6993-5508
Amir ShaikhPain Research and Intervention Center (PRICE), University of Florida, Gainesville, FL 32611, USA.ORCID 0009-0004-0155-3050
Patricia Lopes CabreraPain Research and Intervention Center (PRICE), University of Florida, Gainesville, FL 32611, USA.ORCID 0009-0001-4544-6212
Selenia RubioPain Research and Intervention Center (PRICE), University of Florida, Gainesville, FL 32611, USA.ORCID 0000-0001-6139-673X
Margarete C Ribeiro-DasilvaPain Research and Intervention Center (PRICE), University of Florida, Gainesville, FL 32611, USA.ORCID 0000-0003-3224-4045
Roger B FillingimPain Research and Intervention Center (PRICE), University of Florida, Gainesville, FL 32611, USA.ORCID 0000-0002-7699-8183

Funding

Photobiomodulation for the management of Temporomandibular disorder painUH3DE030433 · NIDCR · UNIVERSITY OF FLORIDA · PI Roger B Fillingim, Margarete C Ribeiro-Dasilva · 2023 to 2026
$3.1M
National Institutes of Health (NIH) and the National Institute of Dental and Craniofacial Research (NIDCR) 3UH3DE030433-04S1 and 5UH3DE030433-04NIDCR NIH HHS UH3 DE030433
6 · The paper itself

Abstract

Temporomandibular disorders (TMDs) represent a group of conditions affecting the temporomandibular joint and its associated musculature. TMD is the leading cause of chronic orofacial pain. Current assessment relies heavily on patient-reported outcomes, which capture pain intensity and its impact but provide limited mechanistic or functional insight. This narrative conceptual review proposes a framework for investigating vocal, oropharyngeal, and cognitive-linguistic (VOCL) features as candidate behavioral biomarkers for precision pain phenotyping in TMD. We synthesize the literature from TMD and related neurological and chronic pain conditions to examine how alterations in neuromuscular control, autonomic regulation, and cognitive burden could plausibly manifest as changes in acoustic voice metrics, motor speech performance, swallowing function, and cognitive-linguistic tasks. Given the limited TMD-specific empirical evidence available to date, we outline a staged validation roadmap that specifies TMD subgroups, study designs, confounder control strategies, and reliability considerations necessary before clinical application. While promising, VOCL features should be regarded as investigational constructs requiring rigorous validation. Establishing standardized protocols and integrating VOCL measures with psychological and physiological domains may clarify the potential role of VOCL in TMD phenotyping and monitoring.

Indexed as

CognitionFacial PainOropharynxTemporomandibular Joint DisordersBiomarkersDeglutitionHumansPain MeasurementPhenotypeSpeech AcousticsBiomarkersCognitive functionPain phenotypingSpeech acousticsSwallowingTemporomandibular disordersVocal biomarkers

Identifiers

PMID42895003
PMCPMC13678551

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.