Evidence map›Paper›PMID 42894883›Full record

ArticleBrain, behavior, & immunity - health2026

Tissue-specific inflammatory responses to systemic LPS in mice with LysM-lineage Hmgb1 deletion.

James A Johnson, Angar Tsoggerel, Kathryn Fischer, Alexandru Movila, Antentor Hinton, Kimberly Sullivan

Abstract read
In one paragraph

Article in Brain, behavior, & immunity - health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

James A JohnsonDepartment of Biochemistry, Molecular Biology and Pharmacology, The Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
Angar TsoggerelDepartment of Biochemistry, Molecular Biology and Pharmacology, The Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
Kathryn FischerDepartment of Biochemistry, Molecular Biology and Pharmacology, The Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
Alexandru MovilaDepartment of Biomedical Science Indiana University School of Dentistry, Indianapolis, IN, USA.
Antentor HintonDepartment of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, USA.
Kimberly SullivanDepartment of Environmental Health, Boston University School of Public Health, Boston, MA, USA.

Funding

The Neuroimmune Hypothesis of Paraquat: Connecting the Periphery and BrainR01ES028104 · NIEHS · INDIANA UNIVERSITY INDIANAPOLIS · PI BLOCK, MICHELLE L · 2018 to 2022
$2.1M
HMGB1, Chlorpyrifos, and Persistent GWI-like NeuropathologyR01ES029835 · NIEHS · INDIANA UNIVERSITY INDIANAPOLIS · PI BLOCK, MICHELLE L · 2018 to 2022
$1.9M
The Role of Peripheral Immune Cell Trafficking in Ozone-Induced Alzheimer's Disease NeuropathologyR01AG077826 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI Adrian Lynn Oblak · 2025 to 2026
$1.1M
Roles of Periodontal Bacteria-Derived Dihydroceramides in Alzheimer's Disease Exacerbated by Down SyndromeK02AG068595 · NIA · NOVA SOUTHEASTERN UNIVERSITY · PI MOVILA, ALEXANDRU · 2020 to 2024
$908k
BLRD VA I21 BX006307NIA NIH HHS K02 AG068595NIA NIH HHS R01 AG077826NIEHS NIH HHS R01 ES028104NIEHS NIH HHS R01 ES029835
6 · The paper itself

Abstract

Background: Systemic lipopolysaccharide (LPS) exposure induces peripheral inflammation that can engage neuroimmune pathways. High-mobility group box 1 (HMGB1) may contribute to peripheral-central communication, but the role of lysozyme M (LysM)-expressing cells in circulating HMGB1 and compartment-specific inflammatory responses remains unclear. Methods: Male 7-8-week-old Results: LPS increased plasma HMGB1 at 3 h and 7 days without significant genotype differences. Despite comparable circulating HMGB1, LysM-lineage Conclusions: LysM-lineage

Identifiers

PMID42894883
PMCPMC13677236

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.