Evidence map›Paper›PMID 42894875›Full record

ArticlePreventive medicine reports2026

Strategies for recruitment and retention of underrepresented populations in randomized clinical trials in the United States: A mixed-methods study.

Josiah Drakes, Medha Romee Maitra, Jasmine A Silvestri, Emma Britez Ferrante, Dorothy Sheu, Sebastian Castro, Adina Lieberman, Scott Halpern, Meghan Lane-Fall, Rachel Kohn and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Preventive medicine reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Josiah DrakesXavier University of Louisiana, New Orleans, Louisiana, United States.
Medha Romee MaitraPalliative and Advanced Illness Research (PAIR) Center at the University of Pennsylvania, Philadelphia, PA, United States.
Jasmine A SilvestriPalliative and Advanced Illness Research (PAIR) Center at the University of Pennsylvania, Philadelphia, PA, United States.
Emma Britez FerrantePalliative and Advanced Illness Research (PAIR) Center at the University of Pennsylvania, Philadelphia, PA, United States.
Dorothy SheuPalliative and Advanced Illness Research (PAIR) Center at the University of Pennsylvania, Philadelphia, PA, United States.
Sebastian CastroPalliative and Advanced Illness Research (PAIR) Center at the University of Pennsylvania, Philadelphia, PA, United States.
Adina LiebermanPalliative and Advanced Illness Research (PAIR) Center at the University of Pennsylvania, Philadelphia, PA, United States.
Scott HalpernPalliative and Advanced Illness Research (PAIR) Center at the University of Pennsylvania, Philadelphia, PA, United States.
Meghan Lane-FallDepartment of Anesthesiology, Columbia University Vagelos College of Physicians and Surgeons, NY, New York, United States.
Rachel KohnPalliative and Advanced Illness Research (PAIR) Center at the University of Pennsylvania, Philadelphia, PA, United States.
Tamar KlaimanPalliative and Advanced Illness Research (PAIR) Center at the University of Pennsylvania, Philadelphia, PA, United States.
BETTER Center

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: We explored facilitators influencing participation in randomized clinical trials (RCTs) among underrepresented groups in the United States, including Black and Hispanic/Latinx individuals, women, and rural populations. Methods: We recruited a convenience sample of adults from these underrepresented groups to complete an online survey of multiple-choice and open-ended questions about preferences and motivations for RCT participation. Recruitment occurred May through September 2023. Results: Facilitators included regular communication, minimizing participant burden, building trust, fair compensation, and emphasizing the purpose and value of research. Conclusion: To improve inclusivity and generalizability, addressing the barriers to RCT participation for underrepresented groups is crucial. Our results point to the importance of designing RCTs that prioritize transparency, clearly define the research objectives, reduce participant burden, and cultivate trust, while ensuring that compensation and logistical support are equitable and reflect participants' time and effort.

Indexed as

Black, Hispanic/LatinxDiversity, equity, and inclusionHealth disparitiesHealth equityMixed methodsPractice guidelinesRandomized clinical trialsRecruitmentResearch prioritiesRetentionRural populationsSocial justiceUnderrepresented populationsWomen

Identifiers

PMID42894875
PMCPMC13677178

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.