National trends and disparities in coronary artery disease and depression-related mortality in the United States, 1999-2025: A population-based CDC WONDER analysis.

Background: Coronary artery disease (CAD) and depressive disorders frequently coexist, but national mortality patterns involving both conditions remain incompletely characterized. Objective: To evaluate temporal trends and demographic and geographic disparities in mortality involving CAD and depressive or depressive-anxiety disorders in the United States from 1999 to 2025. Methods: We analyzed U.S. residents aged ≥25 years using the CDC WONDER Multiple Cause of Death database. Deaths were included when CAD (ICD-10 I20-I25) and a depressive or depressive-anxiety disorder (F32, F33, or F41.2) were both recorded on the same death certificate, irrespective of underlying or contributing cause. Age-adjusted mortality rates (AAMRs) were standardized to the 2000 U.S. population, and temporal trends were assessed using Joinpoint regression. Data were extracted April 10, 2026; 2025 mortality data were provisional. Urbanization analyses were limited to 1999-2020. Results: Among 85,806 deaths, the mean annual AAMR was 1.42 per 100,000 population. AAMR declined from 1.81 (95% CI, 1.75-1.87) in 1999 to 1.31 (95% CI, 1.26-1.35) in 2025 (AAPC, -1.38%; 95% CI, -2.24 to -0.50; Conclusions: Mortality involving both conditions declined overall but varied substantially across demographic and geographic subgroups, with increases in some younger and middle-aged populations.