Evidence map›Paper›PMID 42894851›Full record

ArticleKidney medicine2026

Epimeric Vitamin D is Not Associated With Arterial Stiffness or Cardiovascular Outcomes in Patients With Advanced CKD.

Monique O Campos, Chien-Yao Sun, Heather N Burney, Yang Li, Gayatri Narayanan, Olivia Carlton, Tzong-Shi Lu, Glenville Jones, Martin Kaufmann, Stephen M S Ting and 3 more

Abstract read
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In one paragraph

Article in Kidney medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Monique O CamposDivision of Nephrology & Hypertension, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Chien-Yao SunDivision of Nephrology & Hypertension, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Heather N BurneyDepartment of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN.
Yang LiDepartment of Biostatistics and Health Data Science and Richard M. Fairbanks School of Public Health, Indiana University School of Medicine, Indianapolis, IN.
Gayatri NarayananDivision of Nephrology & Hypertension, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Olivia CarltonDivision of Nephrology & Hypertension, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Tzong-Shi LuRenal Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Glenville JonesDepartment of Biomedical and Molecular Sciences and Medicine, Queen's University, Kingston, Ontario, Canada.
Martin KaufmannDepartment of Biomedical and Molecular Sciences and Medicine, Queen's University, Kingston, Ontario, Canada.
Stephen M S TingDepartment of Medicine, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Daniel ZehnderDepartment of Nephrology and Department of Acute Medicine, North Cumbria University Hospital NHS Trust, Carlisle, UK.
Thomas HiemstraCambridge Clinical Trials Unit and School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Kenneth LimDivision of Nephrology & Hypertension, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.

Funding

Redefining cardiovascular risk assessment in dialysis patients (ROCK-D) studyR01HL166747 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI Kenneth Lim · 2023 to 2026
$3.0M
NHLBI NIH HHS R01 HL166747
6 · The paper itself

Abstract

Rationale & Objective: 3-epi-25(OH)D Study Design: A prospective observational study. Setting & Participants: A total of 270 patients with advanced CKD using the Cambridge Coventry Vascular cohort. Exposure s or Predictor s: Baseline 3-epi-25(OH)D Outcome s: Arterial stiffness was assessed by carotid-femoral pulse wave velocity (PWV) and augmentation index (AIx75). Longitudinal outcomes included a composite of major CV events and all-cause mortality. Analytical Approach: Baseline 3-epi-25(OH)D Results: Among 270 participants, quartiles were Q1 < 0.30 ng/mL (n = 64), Q2: 0.30-0.456 ng/mL (n = 71), Q3: 0.457-0.729 ng/mL (n = 68), and Q4 ≥ 0.73 ng/mL (n = 67). Strata were similar in age (44.9 years), sex, and BMI (all Limitations: Observational design with possible residual confounding. Conclusion: In advanced CKD, 3-epi-25(OH)D

Indexed as

Arterial stiffnesscardiovascular outcomeschronic kidney diseaseepimeric vitamin Dmortality

Identifiers

PMID42894851
PMCPMC13677220

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.