ArticleEJHaem2026
Comparative Efficacy and Safety of Bruton Tyrosine Kinase and Spleen Tyrosine Kinase Inhibitors in Immune Thrombocytopenia: A Network Meta-Analysis of Clinical Trials.
Article in EJHaem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Targeted kinase inhibitors have shown statistically and clinically significant improvements in platelet response among patients with primary ITP, supporting their utility as effective targeted therapeutic strategies. We evaluated the efficacy and safety of Bruton tyrosine kinase (BTK) and spleen tyrosine kinase (SYK) inhibitors in primary immune thrombocytopenia (ITP) using network meta-analysis. Methods: Following PRISMA-NMA guidelines, five trials, including 660 patients, were analyzed. Comparing rilzabrutinib, HMPL-523 (sovleplenib), and fostamatinib against placebo. The primary outcome was platelet response (≥ 50 × 10 Results: All treatments significantly improved platelet response versus placebo. Sovleplenib 300 mg showed the greatest efficacy (RR = 30.51, 95% CI: 4.33-214.90), followed by rilzabrutinib 400 mg (RR = 16.60, 95% CI: 2.32-118.92), and fostamatinib 100 mg (RR = 6.51, 95% CI: 1.62-26.08). No significant differences were observed in overall adverse events. Treatment discontinuation risk was lowest with fostamatinib (RR = 1.10, 95% CI: 0.29-4.27). Conclusion: Targeted kinase inhibitors demonstrated clinically meaningful improvements in platelet response in primary ITP, supporting their role as effective targeted therapeutic options. Comparative safety profiles varied, and no clear class-level superiority was established. Therefore, further large head-to-head trials with standardized outcome definitions and longer follow-up durations are needed to confirm long-term efficacy, safety, and consistency of treatment effects across clinical outcomes. Trial Registration: The authors have confirmed clinical trial registration is not needed for this submission.
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Registered trials
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