Evidence map›Paper›PMID 42894822›Full record

ArticleBioactive materials2027

From passive fillers to active implants: A 3D-printed trilayer piezoelectric scaffold recapitulating native bone hierarchy.

Yanbo Shan, Suyun Li, Yixuan Wang, Ye Lei, Gang Wang, Qing Zhou, Yuzheng Lu, Yanbin Wu, Hongyu Jiang, Zhengrui Zhou and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yanbo ShanChinese PLA Medical School, Beijing, 100853, PR China.
Suyun LiInstitute of Advanced Structure Technology, Beijing Institute of Technology, Beijing, 100081, PR China.
Yixuan WangInstitute of Advanced Structure Technology, Beijing Institute of Technology, Beijing, 100081, PR China.
Ye LeiInstitute of Stomatology & Oral Maxilla Facial Key Laboratory, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, PR China.
Gang WangInstitute of Stomatology & Oral Maxilla Facial Key Laboratory, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, PR China.
Qing ZhouInstitute of Advanced Structure Technology, Beijing Institute of Technology, Beijing, 100081, PR China.
Yuzheng LuInstitute of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, Beijing Key Laboratory of Bio-Fabrication and Regenerative Translation Applications for Orthopedic Tissues and Organs, Beijing, 100048, PR China.
Yanbin WuInstitute of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, Beijing Key Laboratory of Bio-Fabrication and Regenerative Translation Applications for Orthopedic Tissues and Organs, Beijing, 100048, PR China.
Hongyu JiangInstitute of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, Beijing Key Laboratory of Bio-Fabrication and Regenerative Translation Applications for Orthopedic Tissues and Organs, Beijing, 100048, PR China.
Zhengrui ZhouInstitute of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, Beijing Key Laboratory of Bio-Fabrication and Regenerative Translation Applications for Orthopedic Tissues and Organs, Beijing, 100048, PR China.
Cheng HuangInstitute of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, Beijing Key Laboratory of Bio-Fabrication and Regenerative Translation Applications for Orthopedic Tissues and Organs, Beijing, 100048, PR China.
Shaoyang XuInstitute of Stomatology & Oral Maxilla Facial Key Laboratory, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, PR China.
Ning WenInstitute of Stomatology & Oral Maxilla Facial Key Laboratory, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, PR China.
Yu WeiInstitute of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, Beijing Key Laboratory of Bio-Fabrication and Regenerative Translation Applications for Orthopedic Tissues and Organs, Beijing, 100048, PR China.
Rujie HeInstitute of Advanced Structure Technology, Beijing Institute of Technology, Beijing, 100081, PR China.
Lisheng ZhaoInstitute of Stomatology & Oral Maxilla Facial Key Laboratory, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Critical-sized alveolar bone defects affect over 10 million patients annually, yet current synthetic bone substitutes act as passive osteoconductive fillers with unpredictable outcomes. Native bone, by contrast, achieves robust regeneration through a trilayered hierarchy of cancellous, cortical, and metabolically active periosteal tissues, with intrinsic piezoelectricity converting mechanical loading into endogenous electrical cues. While piezoelectric biomaterials have emerged as promising active implants, existing homogeneous scaffolds fail to recapitulate native bone's structural complexity and electromechanical coupling; to date, no work has combined this trilayer architecture with piezoelectric functionality in a single construct. Here we report a trilayer bioinspired piezoelectric scaffold fabricated via a two-step conformal 3D printing strategy, composed of a strontium-doped β-tricalcium phosphate (Sr-β-TCP) triply periodic minimal surface (TPMS) cancellous layer, a dense cortical layer, and a barium titanate/silk fibroin (BTO/SF) piezoelectric periosteal layer. Under non-invasive low-intensity pulsed ultrasound (LIPUS) stimulation, the scaffold generates bioelectrical signals that support robust osteogenic activity and pro-angiogenic potential

Indexed as

BiomimeticsBone regenerationLow-intensity pulsed ultrasound (LIPUS)Piezoelectric scaffoldsThree-dimensional (3D) printing

Identifiers

PMID42894822
PMCPMC13677041

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.