Evidence map›Paper›PMID 42894810›Full record

ArticleResuscitation plus2026

Prehospital predictors of clinical outcomes in out-of-hospital cardiac arrest with pulseless electrical activity: a JCS-ReSS report.

Shumpei Kosugi, Yasunori Ueda, Haruhiko Abe, Taro Takeuchi, Koichi Inoue, Yasushi Matsumura, Naohiro Yonemoto, Tetsuya Matoba, Yoshio Tahara

Abstract read
In one paragraph

Article in Resuscitation plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shumpei KosugiCardiovascular Division, National Hospital Organization Osaka National Hospital, 2-1-14 Hoenzaka, Chuo-ku, Osaka 540-0006, Japan.
Yasunori UedaCardiovascular Division, National Hospital Organization Osaka National Hospital, 2-1-14 Hoenzaka, Chuo-ku, Osaka 540-0006, Japan.
Haruhiko AbeCardiovascular Division, National Hospital Organization Osaka National Hospital, 2-1-14 Hoenzaka, Chuo-ku, Osaka 540-0006, Japan.
Taro TakeuchiCardiovascular Division, National Hospital Organization Osaka National Hospital, 2-1-14 Hoenzaka, Chuo-ku, Osaka 540-0006, Japan.
Koichi InoueCardiovascular Division, National Hospital Organization Osaka National Hospital, 2-1-14 Hoenzaka, Chuo-ku, Osaka 540-0006, Japan.
Yasushi MatsumuraCardiovascular Division, National Hospital Organization Osaka National Hospital, 2-1-14 Hoenzaka, Chuo-ku, Osaka 540-0006, Japan.
Naohiro YonemotoJapanese Circulation Society Resuscitation Science Study (JCS-ReSS) Group, Japan.
Tetsuya MatobaJapanese Circulation Society Resuscitation Science Study (JCS-ReSS) Group, Japan.
Yoshio TaharaJapanese Circulation Society Resuscitation Science Study (JCS-ReSS) Group, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Out-of-hospital cardiac arrest (OHCA) with pulseless electrical activity (PEA) has a poor prognosis and is aetiologically heterogeneous. We aimed to identify prehospital predictors of a favourable outcome, overall and by presumed aetiology. Methods: This nationwide cohort study analysed 442,630 adults with OHCA and an initial rhythm of PEA from the All-Japan Utstein Registry between 2005 and 2024. The primary outcome was a favourable neurological outcome at 1 month. Two models were fitted, at the scene and at hospital arrival, each also within each aetiology. Epinephrine and advanced airway management (AAM) were assessed by time-dependent propensity score sequential matching. Results: At the scene, a witnessed arrest (risk ratio [RR], 1.65) predicted a favourable neurological outcome, and a longer response time predicted a worse one (RR, 0.66; 10 versus 5 min). The gradient with age was steeper in cardiac than non-cardiac PEA (RR, 0.38 versus 0.78). At hospital arrival, prehospital return of spontaneous circulation (RR, 23.31) was the strongest predictor, but conversion to a shockable rhythm predicted a favourable outcome only in cardiac PEA and a worse outcome in non-cardiac PEA (RR, 1.37 versus 0.73). Standardised to a common covariate distribution, 1-month survival was higher in non-cardiac PEA, whereas a favourable neurological outcome was more likely in cardiac PEA. After time-dependent adjustment, the apparent harm from epinephrine and AAM was attenuated. Conclusions: Prehospital information available before hospital arrival predicted a favourable neurological outcome, but its prognostic meaning depended on the presumed aetiology. These independent prehospital predictors could inform future risk stratification.

Indexed as

AetiologyCardiopulmonary resuscitationElectromechanical dissociationEpidemiologyPrognosticationRisk factors

Identifiers

PMID42894810
PMCPMC13676978

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.