Evidence map›Paper›PMID 42894802›Full record

ArticleiScience2026

CD8

Kuan Li, Kaibinuer Ainiwaer, Licheng Song, Jinmiao Hu, Yafan Yang, Yimeng Liu, Hongwei Li, Shiqi Xu, Youyang Wang, Juan Yin and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kuan LiDepartment of Basic Medicine, Haihe Clinical School, Tianjin Medical University, Tianjin 300350, China.
Kaibinuer AiniwaerDepartment of Basic Medicine, Haihe Clinical School, Tianjin Medical University, Tianjin 300350, China.
Licheng SongSenior Department of Respiratory and Critical Care Medicine, the Eighth Medical Center of Chinese PLA General Hospital, Beijing 100039, China.
Jinmiao HuDepartment of Respiratory Medicine, Haihe Clinical School, Tianjin Medical University, Tianjin 300350, China.
Yafan YangDepartment of Anaesthesiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Yimeng LiuTianjin Key Laboratory of Lung Regenerative Medicine, Haihe Hospital, Tianjin University, Tianjin 300350, China.
Hongwei LiDepartment of Respiratory Medicine, Haihe Clinical School, Tianjin Medical University, Tianjin 300350, China.
Shiqi XuTianjin Key Laboratory of Lung Regenerative Medicine, Haihe Hospital, Tianjin University, Tianjin 300350, China.
Youyang WangTianjin Key Laboratory of Lung Regenerative Medicine, Haihe Hospital, Tianjin University, Tianjin 300350, China.
Juan YinDepartment of Basic Medicine, Haihe Clinical School, Tianjin Medical University, Tianjin 300350, China.
Li LiDepartment of Respiratory Medicine, Haihe Clinical School, Tianjin Medical University, Tianjin 300350, China.
Xing WangDepartment of Respiratory Medicine, Haihe Clinical School, Tianjin Medical University, Tianjin 300350, China.
Xiaoyang HongSenior Department of Pediatrics, the Seventh Medical Center of Chinese PLA General Hospital, Beijing 100700, China.
Lixin XieSenior Department of Respiratory and Critical Care Medicine, the Eighth Medical Center of Chinese PLA General Hospital, Beijing 100039, China.
Huaiyong ChenDepartment of Basic Medicine, Haihe Clinical School, Tianjin Medical University, Tianjin 300350, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Viral acute respiratory distress syndrome (ARDS) exhibits distinct clinical outcomes across age groups, but the immune mechanisms underlying this disparity remain unclear. Here, we integrated single-cell transcriptomic profiling, T cell receptor repertoire analysis, serum proteomics, and functional validation to characterize age-dependent T cell remodeling in influenza-associated ARDS. Adult ARDS was characterized by reduced T cell receptor diversity, expansion of CD8

Indexed as

acute respiratory distress syndromeCD8+ effector memory T cellsgranzyme B hyperactivationimmune agingTGFB1-RUNX3-PRDM1 regulatory axis

Identifiers

PMID42894802
PMCPMC13676981

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.