Evidence map›Paper›PMID 42894780›Full record

ArticleBrain, behavior, & immunity - health2026

Pathways from chronic stress to cognitive decline: A multi-cohort mediation analysis of inflammation and immune-related gene expression.

Laura Laiton, Mohamed Abdelrahman, Idan Shalev, Martin J Sliwinski, Yogasudha Veturi

Abstract read
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In one paragraph

Article in Brain, behavior, & immunity - health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Laura LaitonBioinformatics and Genomics, Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA.
Mohamed AbdelrahmanDeparment of Biobehavioral Health, The Pennsylvania State University, University Park, PA, 16802, USA.
Idan ShalevBioinformatics and Genomics, Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA.
Martin J SliwinskiDeparment of Human Development and Family Studies, The Pennsylvania State University, University Park, PA, 16802, USA.
Yogasudha VeturiBioinformatics and Genomics, Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic stress is a well-established risk factor for poorer cognitive aging, but the biological mechanisms underlying these associations remain unclear. Inflammatory processes have been proposed as key mechanisms, but evidence across large, independent cohorts is limited. We conducted statistical mediation analyses to examine whether inflammatory biomarkers and immune-related gene expression show indirect effect estimates consistent with mediating associations between chronic stress and cognitive performance in two population-based cohorts: Midlife in the United States Study (MIDUS;

Indexed as

Childhood adversityChronic stressCRPCTRAICAM-1Inflammatory biomarkersMediation analysisProcessing speedReasoningSocial isolation

Identifiers

PMID42894780
PMCPMC13676912

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.